Amaç: Bu çalışmanın amacı Graves hastalığı, Hashimoto tiroiditli ve kontrol grubundaki bireylerin, tükürük bezlerinde Tc-99m Metoksiizobutrilizonitril (Tc-99m MIBI) tutulumunun değişimini araştırmaktır. 

Aim: The aim of this study was to determine the involvement in the salivary glands of the patients with Graves’ Disease, Hashimoto Thyroiditis and controls by detecting the changes of Tc-99m Methoxyisobutylisonitrile (Tc-99m MIBI) uptake. Material and Methods: The study was conducted between January 2008 and December 2009. 19 patients with Graves’ disease (6 men, 13 women), 28 Hashimoto Thyroiditis patients (5 men, 23 women) and 11 euthyroid controls (4 men, 7 women) were evaluated retrospectively. Uptake values of parotid and submandibular glands were calculated by drawing elliptical ROIs (region of interest) and using the formula for uptake calculation. Result: In all three groups, in parotis glands, a statistical significant difference between Tc-99m MIBI uptake was not detected. The Tc-99m MIBI upateke values in submandibular glands were statistically different among patients with Graves’Disease, Hashimoto Thyroiditis, as well as in Control group (p<0.05). Conclusion: We concluded that the different uptake values of Tc-99m-MIBI in submandibular glands in Graves disease and Hashimoto thyroiditis  as compared to the control group patient would be results of  the histopathological features, such as autoimmunity, high mitochondria number and inflammatory reaction