Kombine hematolojik inflamatuar indekslerin akut pankreatit hastalarında kötü sonlanımı öngörmedeki rolü

Amaç Akut pankreatit hastalarında NLPR, AISI ve SIRI nın 7günden fazla hastane yatışı, yoğun bakım ihtiyacı ve 30 günlük mortaliteyi öngörebilirliğini değerlendirmek amaçlandı. Materyal ve Metod Bu retrospektif gözlemsel çalışma, 15 Temmuz 2017 ile 15 Şubat 2021 tarihleri arasında XXX Hastanesi acil tıp kliniğine başvuran akut pankreatit tanılı hastalarda yapılmıştır. İstatistiksel analiz için SPSS v.26.0 kullanıldı. Bulgular Çalışmamıza 592 hasta dahil edilmiş olup, %58,3’ü kadındı. NLPR yüksekliği ile 7 günden daha uzun süre hastane kalış süresi arasında istatistiksel anlamlılık tespit edildi (p=0.01). AISI ve SIRI ile ise hastanede kalış süresi arasında istatistiksel olarak anlamlı ilişki tespit edilemedi (sırası ile p=0.16, p=0.19). Hastalarımızın %5.1’i ex oldu. NLPR yüksekliği ile mortalite arasında istatistiksel olarak anlamlı ilişki mevcuttu (p=0.03). AISI ve SIRI ile mortalite arasında istatistiksel olarak anlamlı ilişki tespit edilemedi (sırası ile p=0.866, p=0.311). NLPR yüksekliği ile yoğun bakıma yatış arasında istatistiksel olarak anlamlı ilişki mevcuttu (p=0.018). AISI ve SIRI ile yoğun bakıma yatış arasında istatistiksel olarak anlamlı ilişki tespit edilemedi (p=0.89, p=0.6) Sonuç Akut pankreatit, ciddi yaklaşım gerektiren enflamatuar bir süreçtir. Hematolojik parametreler prognozu öngörmede yardımcıdırlar fakat akut pankreatit yönetiminde farklı şekillerde geliştirilmiş hematolojik indekslere ihtiyaç vardır.

Anahtar Kelimeler:

akut pankreatit, NLPR, AISI, SIRI

The role of combined hematological inflammatory indices in predicting poor outcomes in patients with acute pancreatitis

Aim The aim of the instant study is to evaluate the predictability of AISI, NLPR, and SIRI in patients with acute pancreatitis, which predicts more than 7 days of hospitalization, the need for intensive care, and 30-day mortality. Material and Method This retrospective observational study was conducted in patients diagnosed with acute pancreatitis who applied to the emergency medicine clinic of XXX Hospital between July 15, 2017 and February 15, 2021.Statistical analysis was performed using SPSS v. 26.0. Results The study included 592 patients, 58.3% of which were women. A statistically significant difference was found between high NLPR, and hospital stay longer than 7 days (p = 0.01). No statistically significant correlation was found between AISI and SIRI and the length of hospital stay (p = 0.16, p = 0.19, respectively). There was a statistically significant correlation between high NLPR, and mortality (p = 0.03). No statistically significant correlation was found between AISI, SIRI, and mortality (p = 0.866, p = 0.311, respectively). There was a statistically significant correlation between high NLPR, and hospitalization in the intensive care unit (p = 0.018) No statistically significant relationship was found between AISI, SIRI, and admission to the intensive care unit (p = 0.89, p = 0.6, respectively). Conclusion Acute pancreatitis is an inflammatory process that requires serious approach. Hematological parameters are helpful in predicting the prognosis, but there is a need for differently developed hematological indices in managing acute pancreatitis.

Keywords:

acute pancreatitis, NLPR, AISI, SIRI,

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