Bahar Çuhacı Çakır, Ceyda Tuna Kırsaçlıoğlu, Emine Kaygı Tartıcı, Fatma Demirel

Bebek Ve Çocuklarda Geçici Hiperfosfatazemi: 43 Olguluk Retrospektif Bir Çalişma

Amaç: Kliniğimizde 3 yıllık bir süre boyunca yüksek plazma ALP düzeylerinin prevalansını ve klinik özelliklerini tanımlamak.Gereç ve Yöntem: artmış ALP düzeyleri olan 5 yaşın altındaki 533 çocuğunu geriye dönük olarak taradık ve frekans, mevsimsel dalgalanma, yaş dağılımı ve cinsiyet farklılıklarını araştırdık.Bulgular: Yirmi dört hasta (% 55.8) kızdı ve yaş ortalaması 7.48 ± 12.77 (1-60) ay idi. Ortalama alkalin fosfataz (ALP) düzeyi 1402.23 ± 440.4 U / L (1038-3135 U / L) ve üst aralıktan 3.33 ± 1.04 (2.47-7.46) kat daha yüksekti. ALP seviyeleri, ortalama 2.5 ± 1.1 (1-5) aylık bir süre içinde normale döndü.Sonuç: Bu iyi huylu antitenin erken tanınması, gereksiz testlerden kaçınmaya yardımcı ollabilir

Anahtar Kelimeler:

hiperfosfatazemi, bebeklik, çocuklar

Transient hyperphosphatasemia in infants and children: a retrospective study of 43 cases

Objective: To describe the prevalence and clinical characteristics of elevated plasma ALP levels during a period of 3 years at our clinic. Material and Methods: We reviewed 533 children, retrospectively, to investigate the frequency, seasonal fluctuation, age distribution, and sex differences of the patients with the elevated ALP levels in younger than 5 years old children. Results: Twenty-four of the patients were girls (55.8%), and the mean age of the patients was 7.48±12.77 (1-60) months. The mean serum alkaline phosphatase (ALP) level was 1402.23 ± 440.4 U/L (1038-3135 U/L) and it was 3.33±1.04 (2.47-7.46) fold above upper range. Their ALP levels returned to normal in a mean period of 2.5 ± 1.1 (1 to 5) months. Conclusion: Early recognition of this benign entity, should help to avoid unnecessary tests.

Keywords:

hyperphosphatasemia, infancy, children,

PDF

___

1. Tolaymat N, de Melo MC. Benign transient hyperphosphatasemia of infancy and childhood. South Med J 2000; 93: 1162-64.
2. Behúlová D, Bzdúch V, Holesová D, et al. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000; 46: 1868-69.
3. Kraut JR, Metrick M, Maxwell NR, et al: Isoenzyme studies in transient hyperphosphatasemia of infancy. ten new cases and a review of the literature. Am J Dis Child 1985; 139:736-740
4. Huh SY, Feldman HA, et al. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009; 124: 703-9.
5. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011; 24: 351-3.
6. Carroll AJ, Coakley JC. Transient hyperphosphatasaemia: an important condition to recognize. J Paediatr Child Health 2001; 37: 359-62.
7. Otero JL, González-Peralta RP, Andres JM, et al. Elevated alkaline phosphatase in children: An algorithm to determine when a "Wait and See" approach is optimal. Clin Med Insights Pediatr 2011; 5: 15-8.
8. Gualco G, Lava SA, Garzoni L, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013; 57: 167-71.
9. Lo SF. Reference Intervals for Laboratory Tests and Procedures. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: WB Saunders, 2011: 2466.
10. Kutilek S, Cervickova B, Bebova P, et al. Normal bone turnover in transient hyperphosphatasemia. J Clin Res Pediatr Endocrinol 2012; 4: 154-6.
11. Stein P, Rosalki SB, Foo AY, et al. Transient hyperphosphatasemia of infancy and early childhood: clinical and biochemical features of 21 cases and literature review. Clin Chem 1987; 33: 313-8.
12. Eymann A, Cacchiarelli N, Alonso G, et al. Benign transient hyperphosphatasemia of infancy. A common benign scenario, a big concern for a pediatrician. J Pediatr Endocrinol Metab 2010; 23: 927-30.
13. Turan S, Topcu B, Gökçe İ, et al. Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets. J Clin Res Pediatr Endocrinol 2011; 3: 7-11.
14. Suzuki M, Okazaki T, Nagai T, et al. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002; 33: 215-8.