Faruk KILINÇ, Fatih DEMİRCAN, Zafer MENGELOĞLU, Affan DENK

Evaluation of epidemiological data of 541 patients with brucellosis in Siirt, a city in south-eastern Anatolia

Amaç: Ülkemiz açısından önem arz eden ve önlenebilir birenfeksiyon olan bruselloz ile ilgili deneyimlerimizi sunarakkonuyu irdelemek amacıyla 541 bruselloz olgusu değer-lendirilmiştir. Yöntemler: Ocak 2006-Aralık 2010 tarihleri arasında yatı- rılarak takip ve tedavileri yapılan 1210 hasta geriye dönük olarak incelenmiş, Rose Bengal pozitif ve Wright aglutinas- yon testi titresi 1/160 ve üzeri olan 541 bruselloz olgusu çalışmaya dahil edilmiştir. Bulgular: Çalışmamıza alınan 541olgunun %53,6’sı erkek %46,4’ü kadın olup, yaş ortalamaları 41,23±2,7 idi. Hem erkeklerde hem de kadınlarda brusellozun en sık görüldü- ğü yaş aralığı 31-50 yaş arası olmuştur. Hematolojik bul- gulardan hastaların %67’sinde sedimentasyon 20-40 mm/ saat, %53’ünde lökosit sayısı normal aralıkta iken, has- taların %36’sında lökositoz, %10’unda lökopeni, %8’inde trombositopeni bulunmuştur. En sık gözlenen üç semptom eklem ağrısı (%90), kas ağrısı (%75) ve halsizlik (%70) ol- muştur. En sık tutulan sistemler sırasıyla kas iskelet (%28), hematolojik (%22) ve gastrointestinal sistemler (%20) ol- muştur. Kas iskelet sistemi bulgularından sakroileit (%20 ), hematolojik bulgulardan anemi (%14) ve gastrointesti- nal sistemden ise karaciğer fonksiyon bozukluğu (%12) en sık raslanan sistemik bulgular olmuştur. Bu endemik hastalığın en çok (%30) gözlemlendiği ay Mayıs olmuştur. Olgularımızın %47’sinin bruselloz açısından riskli meslek olan tarım ve hayvancılıkla uğraşıyor olması, bruselloz epi- demiolojisi hakkındaki klasik bilgileri destekler niteliktedir. Sonuç: Önleyici programlara rağmen bu enfeksiyonun oranı hala yüksek olup, hem insan sağlığını hem de hay- vancılık sektörünü etkiler. Bundan dolayı bu yaygın en- feksiyon hastalığı ile ilgili daha geniş serilerin irdelendiği çalışmalara ihtiyaç duyulmaktadır.

Güneydoğu Anadolu Bölgesinde bulunan Siirt ilinde 541 bruselloz olgusunun epidemiyolojik verilerinin irdelenmesi

Objectives: We intended to examine 541 brucellosis cas-es by offering our experiences regarding this preventableinfectious disease that is significant for our country.Methods: We evaluated 1210 hospitalized patients be- tween the dates of January 2006 and December 2010 in Siirt General Hospital and 541 brucellosis cases were re- viewed retrospectively. Patients with Rose Bengal plate test positive and has Wright agglutination test a titer of 1:160 or higher were included in this study. Results: A 53.6% of brucellosis cases were male and 46.4% were female. The mean age (±SD) of patients was 41.23±2.7 years. Between the ages 31 and 50 is the range brucellosis is most commonly encountered in both men and women. Hematological evidence discov- ered that for 67% of patient’s sedimentation is 20-40 mm/ hour, 53% leukocyte count is in normal range, 36% of pa- tients had leukocytosis, 10% had leukopenia, and 8% had thrombocytopenia. Most common three symptoms were joint pain (90%), myalgia (75%) and fatigue (70%). The most involved systems were musculoskeletal (28%), he- matological (22%), and gastrointestinal systems (20%). Most commonly encountered systemic findings were sac- roiliitis (20%), anemia (14%) and liver dysfunction (12%). Brucella was observed most commonly is May (30%) in Siirt. A 47% of our cases are occupied in agriculture and stockbreeding that are risky occupations regarding bru- cellosis, supports the conventional data regarding brucel- losis epidemiology. Conclusion: Despite the campaigns, infection rate is still high and it affects both animal industry and human health in our country. Data about brucellosis should be validated by large multicenter studies.

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