Agressive angiomyxoma: Case report

Agresif anjiomiksoma nadir görülen benign mezenşimal tümördür. Sıklıkla üreme çağı kadınlarda genital, pelvik ve perineal bölgelerde görülür. Agresif anjiomiksomada lokal rekürrens riski yüksektir. Tanıda agresif anjiomiksoma bartolin kisti, lipoma ve vajinal kist ile karışır. Bu iyi huylu tümörde genellikle stromal invazyon görülür ve geniş lokal eksizyon yapılmalıdır. GnRH agonistleri ile tedavi primer yada rekürren agresif anjiomiksoma olgularında uygulanabilir. Vulvar kitle tanısı ile geniş lokal eksizyon tedavisi uyguladığımız olguyu sunduk.

Agresif anjiomixoma: Olgu sunumu

Aggressive angiomyxoma is a rare benign mesenchymal neoplasm. It is often diagnosed in genital, pelvic and perineal region of women in reproductive ages. Aggressive angiomyxoma is associated with a high risk of local recurrence. Aggressive angiomyxoma is mixed with Bartholin s gland cyst, lipoma and vaginal cysts in diagnosis. Generally, stromal invasion is detected in these benign neoplasms. Therefore, wide local excision should be performed to treat. GnRH agonists could be administered in patient with aggressive angiomyxoma, either primary or recurrent. We reported a case with vulvar aggressive angiomyxoma presented with vulvar mass and treated with wide local excision.

PDF

___

1. Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum: report of nine cases of a distinctive type of gynecologic soft tissue neoplasm. Am J Surg Pathol 1983;7(5):463-75.
2. McCluggage WG. A review and update of morphologically bland vulvovaginal mesenchymal neoplasms. Int J Gynecol Pathol 2005;24(1):26-38.
3. Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM. Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer 1996;78(1):79-90.
4. Iezzoni JC, Fechner RE, Wong LE, et al. Aggressive angiomyxoma in males. A report of four cases. Am J Clin Pathol 1995;104(4):391-6.
5. Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: update and review. Histopathology 2000;36(2):97-108.
6. Gungor T, Zengeroglu S, Kaleli A, Kuzey GM. Aggressive angiomyxoma of the vulva and vagina. A common problem: misdiagnosis. Eur J Obstet Gynecol Reprod Biol 2004; 112(1): 114-6.
7. Blandamura S, Cruz J, Faure Vergara L, et al. Aggressive angiomyxoma. A second case of metastasis with patients death. Hum Pathol 2003; 34(10):1072-4.
8. Amezcua CA, Begley SJ, Mata N, Felix JC,Ballard CA. Aggressive angiomyxoma of the female genital tract: a clinicopathologic and immunohistochemical study of 12cases. Int J Gynecol Cancer 2005;15(1):140-5.
9. Cinel L, Taner D, Nabaei SM, Dogan M. Aggressive angiomyxoma of the vagina. Report of a distinctive type gynaecologic soft tissue neoplasm. Acta Obstet Gynecol Scand 2000 ;79(3):232-3.
10. van Roggen JF, van Unnik JA, Briaire-de Bruijn IH, Hogendoorn PC. Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of
11 cases with long-term follow-up. Virchows Arch 2005;446(2):157-63.
11. McCluggage WG, Patterson A, Maxwell P. Aggressive angiomyxoma of pelvic parts exhibits oestrogen and progesterone receptor positivity.J Clin Pathol 2000;53(8):603-5.
12. Wang J, Sheng W, Tu X,Shi D,zhu X,Zhang R.Clinicopathologic analysis of angiomyofibroblastoma of the femalegenital tract. Chin Med J (Engl) 2000;113(11):1036-9
13. Laskin WB, Fetsch JF, Tavassoli FA. Angiomyofibroblastoma of the female genital tract: analysis of 17 cases including a lipomatous variant. Hum Pathol 1997;28(9):1046-55
14. Hisaoka M,Kouho H, Aoki T, Daimaru Y, Hashimato H, Angiomyofibroblastoma of the vulva : a clinicopathologic study of seven cases. Pathol Int 1995;45(7):487- 92
15. Fine BA, Munoz AK, Litx LE, et al. Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin - releasing hormone agonist. Gynecol Oncol 2001;81(1):120-2.
16. Poirier M, Fraser R, Meterissian S. Aggressive angiomyxoma of the pelvis: response to luteinizing hormone - releasing hormone agonist. J Clin Oncol 2003;21(18):3535-6.