Ahmet BEYATLİ, Emine Gülçeri GÜLEÇ PEKER, Nursel GÜL, Şule Coşkun CEVHER

Morin (2′,3,4′,5,7-Pentahidroksiflavon) Streptozotosin ile İndüklenen Diyabetik Sıçan Beyin ve Kalp Dokularında Antioksidan Etkisi

Diyabet dünyada bilinen en önemli sağlık problemlerinden birisidir. İnsülin ve oral antidiyabetik ilaçların yan etkilerinden dolayı son yıllarda alternatif tedavilerin araştırılmasında doğal ürünler (özellikle flavonoidler) önemli bir kaynak teşkil etmektedir. Bu çalışma normal ve streptozotosin ile diyabet oluşturulan sıçanlarda morin'in (2′,3,4′,5,7-pentahydroxyflavone) doku antioksidan ve lipid perokidasyon durumu üzerindeki olası olumlu etkisini incelemek için yapılmıştır. Artan reaktif oksijen türleri ve yetersiz antioksidan aktivite diyabet ile ilişkilidir, buda diyabet patogenezinde başlıca sorumludur. Beyin ve kalp antioksidan belirteçleri üzerinede morin'in rolü değerlendirildi. Diyabetik sıçanların beyin ve kalp dokularında normal sıçanlara göre daha yüksek TBARS ve NOx düzeyleri, daha düşük GSH düzeyi gözlendi. Morin muamelesi beyin ve kalp TBARS ve Nox düzeylerindeki artışı anlamlı olarak önledi. Ayrıca morin beyin GSH seviyesinde önemli artış gösterdi. Sonuçlar morin’in diyabetik sıçanlarda antioksidan aktivite gösterdiğini belirtmektedir.

Anahtar Kelimeler:

Morin, Diyabet, Beyin, Kalp, Oksidatif stres

Morin (2′,3,4′,5,7-Pentahydroxyflavon) Antioxidant Effect in Streptozotocin-Induced Diabetic Rat Brain and Heart Tissues

Diabetes mellitus is agreed to be among the biggest public health burdens seen at the world. Recently, the using natural products (flavonoids specially) in diabetes treatment witnessed a growing interest due to insulin's and oral anti-diabetic medicines' unfavorable side effects. The present work is studies the beneficial effects of morin (2′,3,4′,5,7-pentahydroxyflavone) on antioxidant of tissues and lipid peroxidation status in diabetic and non-diabetic rats. Diabetes associated with elevation in reactive oxygen species and deficient in antioxidant activity, which is important aspects for pathogenesis of diabetes. The role of morin on the brain and heart antioxidant markers were estimated. The diabetic rats exhibited elevated levels of TBARS, NOx and GSH levels in brain and heart tissues when compared with healthy animals. The treatments using morin significantly stopped elevation in brain and heart TBARS and NOx levels. Oral administration of morin showed significant increase in GSH level in brain tissue. These results indicated that morin exerts antioxidative activity in diabetic rats.

Keywords:

Morin; Diabetes; Brain; Heart; Oxidative stress, Morin, Diabetes, Brain, Heart,

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