Polikistik over sendromlu kadınlarda cinsel fonksiyon bozukluğu

Amaç: Üreme çağındaki kadınlarda obezite, bozulmuş glikoz toleransı, düzensiz adet döngüsü, infertilite, hirsutizme neden olan ve kadınların % 5 - 10'unu olumsuz etkileyen ciddi endokrinolojik rahatsızlıklardan biri Polikistik over sendromudur (PKOS). Çalışmamızın amacı, PKOS'lu kadınlarda Cinsel İşlev Bozukluğu (CİB) sıklığını araştırmak ve buna neden olabilecek sebeplerin belirlenmesidir. Gereçler ve Yöntem: Çalışmamız, prospektif kesitsel vaka-kontrol çalışmasıdır. Çalışmaya katılmayı kabul eden gönüllülerden tıbbi ve cinsel öykü alınarak 19 sorudan oluşan Kadın Cinsel İşlev Ölçeği (Female Sexual Function Index-FSFI) formu dolduruldu. PKOS’lu kadınların ve kontrol grubunun total FSFI skorları ve alt grup skorları karşılaştırıldı. Bulgular: Olgu ve kontrol grubundaki ortalama yaş sırasıyla 34.35 ± 4.16 ve 34.80 ± 4,36 olarak elde edilmiştir. Ayrıca, iki gruptada da evliliğin ortalama süresi olgu ve kontrol grubu sırasıyla 5.00 ± 2.18 ve 5.76 ± 2.20 olarak elde edilmiştir. Gruplar arası Vücut kitle indeksi (VKİ) , sırasıyla 24.88 ± 2.23 ve 24.77 ± 2,01'dir. Gruplar arası FSFI alt grup skorları incelendiğinde PKOS’lu kadınlarda sadece lubrikasyon skoru istatistiksel açıdan anlamlı olarak yüksekti (3.08 ile 3.60, p-value=0.029). PKOS’lu hastaları VKİ’lerine (Normal, Fazla Ağırlıklı ve Obez) gore gruplara ayırdığımızda, istek ve uyarılma alt grup skorlarında istatistiksel olarak anlamlı farklılık saptandı (sırasıyla P=0.045 ve P=0.050). Sonuç: PKOS’un, kadınların cinsel fonksiyonları üzerine hiçbir etkisi saptanmamıştır. PKOS'lu kadınların lubrikasyonlarının kontrol grubuna gore daha yüksek olduğu tespit edilmiştir. Obezitenin de yine cinsel fonksiyon bozukluğu üzerine bir etkisi saptanmamıştır.

Anahtar Kelimeler:

Vücut Kitle İndeksi, FSFI, Polikistik Over Sendromu, Cinsel Fonksiyon Bozukluğu, Cinsel Yaşam Kalitesi

Sexual Dysfunction in Women with Polycystic Ovary Syndrome (PCOS)

Aim: One of the serious endocrinological disturbances which affects 5 to 10% of women in the age of reproduction leading to obesity, disturbed glucose tolerance, irregular menstrual cycle, infertility and hirsutism is Polycystic ovary syndrome (PCOS). This study aimed to investigate Sexual Dysfunction in Women with PCOS. Materials and Method: A prospective cross-sectional case-control study was done. The subdomain sexual function scores and the mean Female Sexual Function Index (FSFI) total scores between controls and the women with PCOS. And the subdomain sexual function scores and the mean FSFI total scores between women with PCOS stratified by BMI. Results: The mean age in two case and control group was 34.35 ± 4.16 and 34.80 ± 4.36 years. Also, the mean duration of marriage in two case and control group was 5.00 ± 2.18 and 5.76 ± 2.20. The mean BMI in two case and control group was 24.88 ± 2.23 and 24.77 ± 2.01. The difference between the groups with all FSFI subdomains, the only difference between the two groups in lubrication was significant (3.08 vs. 3.60, p-value=0.029). Results showed that a significant difference was found among the BMI groups (Normal, Overweight and Obese) in arousal and desire (P=0.045 and P=0.050, respectively). Conclusion: PCOS has no effect on sexual dysfunction of women. Even the sexual function of women with PCOS has been reported to be higher in lubrication. BMI also has no effect on the relationship between PCOS and sexual dysfunction.

Keywords:

Body Mass Index, FSFI, Polycystic Ovary Syndrome, Sexual Dysfunction, Sexual Quality of Life,

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1. Hahn S, Janssen OE, Tan S, et al. Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome. Eur J Endocrinol. 2011;153:853-860.
2. Arrington, R., Cofrancesco, J., & Wu, A. W. Questionnaires to measure sexual quality of life. Quality of Life Research, 2004; 13, 1643–1658. doi: 10.1007/s11136-004-7625-z.
3. Mölleken D, Richter-Appelt H, Stodieck S. Influence of personality on sexual quality of life in epilepsy. Epileptic Disord.2010;12:125–132.
4. Zawadzky, J.K. and Dunaif, A. Diagnosis criteria: towards a rational approach. In Hershmann, J.M. (ed.), Current Issues in Endocrinology and Metabolism. Blackwell, Boston, 1992; 377–384.
5. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004; 81:19–25.
6. Koneru, A., & S, P. Polycystic Ovary Syndrome (PCOS) and Sexual Dysfunctions. Journal of Psychosexual Health,2019; 1-5.
7. Burri A, Spector T . Recent and lifelong sexual dysfunction in a female UK population sample: Prevalence and risk factors. J Sex Med 2011;8(9): 2420–2430.
8. Cindy M. Meston .Validation of the Female Sexual Function Index (FSFI) in Women with Female Orgasmic Disorder and Women with Hypoactive Sexual Desire Disorder, Journal of Sex & Marital Therapy, 2003;29:1, 39-46.
9. Stovall, D. W., Scriver, J. L., Clayton, A. H., Williams, C. D., & Pastore, L. M. Sexual function in women with polycystic ovary syndrome. The journal of sexual medicine, 2012;9(1), 224–230.
10. Elsenbruch, S., Hahn, S., Kowalsky, D., O¨ Ffner, A., Schedlowski, M., Mann, K., & Janssen, O. Quality of Life, Psychosocial Well-Being, and Sexual Satisfaction in Women with Polycystic Ovary Syndrome. The Journal of Clinical Endocrinology & Metabolism, 2003;12(88);5801–5807.
11. Eftekhar, T., Sohrabvand, F., Zabandan, N., Shariat, M., Haghollahi, F., & Ghahghaei-Nezamabadi, A. Sexual dysfunction in patients with polycystic ovary syndrome and its affected domains. Iranian Journal of reproductive medicine, 2014;12(8);539–546.
12. Ercan CM, Coksuer H, Aydogan U, Alanbay I, Keskin U, Karasahin KE et al .Sexual dysfunction assessment and hormonal correlations in patients with polycystic ovary syndrome. Int J Impot Res 2013;25:127–132.
13. Drosdzol, A., Skrzypulec, V., Mazur, B., & awliñska-Chmara, R. Quality of life and marital sexual satisfaction in women with polycystic ovary syndrome. Folia Histochemica, 2007;45, 93-97.
14. Shafti, V., & Shahbazi, S. Comparing Sexual Function and Quality of Life in Polycystic Ovary Syndrome and Healthy Women. Journal of family & reproductive health, 2016;10(2): 92–98.
15. Veras AB, Bruno RV, de Avila MA, Nardi AE. Sexual Dysfunction in Patients with Polycystic Ovary Syndrome: Clinical and Hormonal Correlations. Compr Psychiatry. 2011;52(5):486-9.
16. Thannickal A, Brutocao C, Alsawas M, Morrow A, Zaiem F, Murad MH, & Chattha AJ. Eating, Sleeping and Sexual Function Disorders in Women with Polycystic Ovary Syndrome (PCOS): a systematic review and meta-analysis. Clin Endocrinol (Oxf). 2020;9.
17. Nandalike K, Strauss T, Agarwal C, et al. Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome. J Pediatr. 2011;159(4):591-596.