Fatma BEYAZIT, Havva ORAL, Selen TAFLAN, Muammer DOĞAN, Leyla MOLLAMAHMUTOĞLU

İNTRAUTERİN İNSEMİNASYON SONRASI BAŞARIYI BELİRLEMEDE SPERM PARAMETRELERİNİN PREDİKTİF DEĞERİ: BİR TERSİYER MERKEZ DENEYİMİ

Amaç: İntrauterin inseminasyon IUI , infertil çiftlerin tedavisinde yıllardır yaygın olarak kullanılan bir yöntemdir. IUI tedavisinin başarısı semen kalitesini de içeren birçok faktöre bağlı olarak değişmektedir. Normal semen kalitesi, Dünya Sağlık Örgütü tarafından belirlenen kriterler kullanılarak tanımlanır, fakat bu kriterlerin IUI’daki başarıyı belirlemedeki prognostik değeri azdı. Çünkü WHO’nun normal olarak önerdiği değerlerin altında bile IUI sonrası elde edilen gebelik oranları kabul edilebilir seviyelerdedir Gereçler ve Yöntem: Bu çalışmada, Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi İnfertilite Polikliniği’ne Ocak 2002 ve Haziran 2004 tarihleri arasında müracaat eden, açıklanamayan infertilite veya erkek faktörüne bağlı infertilite nedeniyle kontrollü ovaryan hiperstimülasyon sonrasında IUI tedavisi uygulanmış 379 hasta retrospektif olarak incelendi. Bulgular: Yirmidokuz aylık bir süreçte 379 hastaya toplam 631 IUI siklusu uygulanmıştı. Ortalama hasta yaşı 27.5 ± 5.37 ve ortalama infertilite süresi 4.28 ± 3.02 yıl idi. Gebelikle sonuçlanan 63 IUI işleminin 59’unun %93,7 üç siklus sonunda elde edildiği saptandı. . Çalışmaya alınan hastalarda siklus başına düşen gebe- lik oranı %9.98, hasta başına düşen gebelik oranı ise %16.62 idi. Kadının yaşının genç olması, kısa infertilite süresi ve sekonder infertlite nedenlerinden birinin mevcut olması IUI başarısını pozitif etkilemekteydi. Ancak ovulasyon yöntemi gebelik üzerinde anlamlı bir etkiye sahip değildi. Total motil sperm sayısı TMSS

Anahtar Kelimeler:

İnfertilite, intrauterine insemi- nasyon, total motil sperm sayısı

PREDICTIVE VALUE OF SPERM PARAMETERS FOR PREDICTING SUCCESS AFTER INTRAUTERİNE INSEMINATION: THE EXPERIENCE OF A TERTIARY REFERRAL CENTER

Aim: Intrauterine inseminations IUI are commonly used in the treatment of infertile couples. The effectiveness of IUI depends on many factors, including sperm quality. Normal semen quality is usually verified with the use of the World Health Organization WHO criteria, but these criteria have little prognostic value in IUI, as pregnancy rates after IUI are acceptable even below the WHO thresholds for normal semen quality. Materials and Method: In this study we retrospectively evaluated 379 couples with idiopatic or male factor infertility, who had been treated with IUI after controlled ovarian hyperstimulation in infertility department of Dr. Zekai Tahir Burak Hospital during the time period between January 2002 and June 2004. Results: A total of 379 women underwent 631 cycles of IUI during a 29-months period. Mean age was 27.5 ± 5.37 years and mean infertility duration was 4.28 ± 3.02 years. Fifty nine 93.7% out of 63 pregnancies were obtained in the first three treatment cycles. Pregnancy rate per cycle was 9.98%, and pregnancy rate per couple was 16.62%. A younger age of the female partner, shorter duration of infertility, and the presence of secondary infertility were significantly associated with enhanced success rates with IUI, but the method of ovulation induction did not have an impact on the likelihood of pregnancy. Patients with total motile sperm count TMSC

Keywords:

Infertility, intrauterine insemination, total motile sperm count,

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