Mehmet DEMİREL, İsmail CÖMERTOĞLU, Kadir DEMİRCAN, Esma SARIKAYA, Sümeyya AKYOL

ADAMTS Gen Ailesinin Obstetrik ve Jinekolojideki Yeri

1997 yılında Japon araştırmacılar tarafından kolon kanserinde enflamasyon http://www.bilimterimleri.com - ilişkili gen olarak tanımlanan Trombospondin Motifli Matriks Metalloproteinazlarını A Disintegrin-like and Metalloproteinase with Trombospondin type-1 motif; ADAMTS , günümüzde 19 adet üyesiyle büyük bir gen ailesidir. Hücre-dışı matrikse ECM salınan bu enzimlerin matriksin yapım ve yıkımı, dokuların yeniden düzenlenmesi, pıhtılaşma, fibrozis gibi birçok önemli fizyolojik olayda hayati görevleri vardır. Yine kanser, enflamasyon, kas-iskelet sistemi hastalıkları gibi çeşitli klinik durumların patogenezlerinde de önemlidirler. Son çalışmalarla bu enzimlerin üreme sisteminde de önemli fonksiyonlar üstlendiği anlaşılmaya başlandı. Bu derlemenin amacı, obstetrik ve jinekoloji alanında çalışan araştırmacılara ADAMTS’ler hakkında temel bilgileri sunmak ve patofizyolojideki rolleri hakkında son bulguları aktararak yeni çalışmaların önünü açmaktır.

Anahtar Kelimeler:

ADAMTS genleri, obstetrik ve jinekoloji, hücre matriksi

ADAMTS Gen Ailesinin Obstetrik Ve Jinekolojideki Yeri

Matrix metalloproteinases with thrombospondin motifs A disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif, ADAMTS firstly described as inflammation-related genes in colon carcinoma by Japanese researchers have a large gene family with the current 19 members. These proteinases which are secreted into extracellular matrix have important roles in matrix formation and degradation, remodeling, coagulation, fibrosis and in many other physiological processes. These enzymes are critical in many pathological situations such as cancers, musculoskeletal disorders and autoimmune events. Recent studies about these proteinases showed their importance in the reproductive system as well. The goal of this review is to provide basic information about the roles of ADAMTS enzymes in the pathophysiology of reproductive system diseases to the researchers of obstetric and gynecology field and to open new insights about this subject.

Keywords:

ADAMTS genes, obstetrics and gynecology, cell matrix,

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