Selahattin ÖZTAŞ, Mahmut REÇPER, Sema SARAÇ, Özlen TÜMER, İpek ERDEM, Melahat KURUTEPE

TÜBERKÜLOZ PLÖREZİDE PLEVRA SIVISI VE SERUMDA ÖLÇÜLEN ADENOZİN DEAMİNAZ, GAMA İNTERFERON VE İNTERLÖKİN 18 DÜZEYLERİNİN TANISAL DEĞERİ

Plevral effüzyonla rın özellikle eksudatif plevral efüzyonların ayırıcı tanısı güçtür. Bu çalışmamızda noninvaziv ve kolay uygulanabilir bir yöntem olan adenozindeaminaz (ADA), interferon-gama (IFN-gama), interlökin-18 (IL-18) düzeylerini plevra sıvısı ve serumda ölçerek tanı değerini incelemeyi hedefledik. Ocak 2005-Nisan 2006 tarihleri arasında incelenen 45 tüberküloz plörezili, 45 malign plevral effüzyonlu toplam 90 hasta çalışmaya alındı. Hastalar ın eş zamanlı serum ve plevral sıvı örnekleri alınarak ELISA ve kalorimetrik yöntemler kullanılarak parametreler ölçüldü. Sonuçlar SPSS program ında Kolmogorov Smirnov testi, student t testi Mann Whitney-U testi ve Kikare testi ile değerlendirildi. Tüberküloz plörezide; ADA, IFN-gamma, IL-18 düzeyleri plevra sıvısında seruma göre anlamlı derecede yüksek bulundu (p

Anahtar Kelimeler:

Interleukin-18, Interferon-gama, Adenozin deaminaz, Plörezi, Tüberküloz, Malignite

ADA, IFN-GAMMA AND IL-18 LEVELS IN PLEURAL FLUID AND SERUM FOR THE DIAGNOSIS OF TUBERCULOUS PLEURITIS

The differential diagnosis of exudative pleural effusions are difficult. The aim of this study was to evaluate the diagnostic value of ADA, IFN-gamma and IL-18 levels in both pleural fluids and sera of patients with pleural effusions. Between January 2005 and April 2006, 45 patients with TB pleuritis and 45 patients with malignant pleural efusion were enrolled in this study. ADA, IFN-gamma and IL-18 and other biochemical parameters were examined in pleural fluid and sera of the patients with ELISA and calorymetric methods. The results were evaluated with SPSS program using Kolmogorov Smirnov test, student t test, Mann Whitney U test and qui square test. ADA, IFN-gamma and IL-18 levels were significantly high in pleural fluid compared with sera of tuberculous pleuritis patients (p

Keywords:

Interleukin-18, Interferon-gamma, Adenosy deaminaz, pleural effusion, Tuberculosis, Malignancy,

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