İleri Evre Akciğer Kanserinde; Yaygın Kanser İnflamasyon İndeksi (ALI), Serum Nötrofil/Lenfosit Oranı (NLR), Trombosit/Lenfosit Oranının (PLR) Prognostik Değeri
Amaç: Akciğer kanseri tüm dünyada en sık görülen ve ölüme neden olan kanser türüdür. Sistemik inflamasyon hem kanser etiyopatogenezinde rol oynadığı hem de kanser hücrelerinde onkojenik değişikliklerden aktiflenebildiği gösterilmiştir. Akciğer kanserinde, prognozunu ve riskli olguları belirlemede sistemik inflamatuar parametrelerin yeri olabileceğini gösteren çalışmalar olmakla beraber sonuçlar halen tartışmalıdır. Çalışmamızda serumdan hesaplanan inflamatuar parametrelerin, akciğer kanserinde prognostik etkisi araştırıldı. Yöntem: Göğüs hastalıkları kliniğimizde 2013-2015 tarihleri arasında tanı alan lokal ileri ve ileri evre akciğer kanserli 115 olgu retrospektif olarak incelendi. Tüm hastaların tanı aşamasında serum örneklerinden hesaplanan; ileri akciğer kanseri inflamasyon indexi (ALI indeksi), serum nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) düzeyleri ile genel sağkalım (OS), hastalıksız sağkalım (PFS) ve tedaviye yanıt değerlendirmeleri arasındaki ilişki ve prognozu öngörmede ki etkisi araştırıldı. Bulgular: Çalışmamızda ileri evre akciğer kanserli olgular da OS için incelendiğinde; ALI ve NLR de istatistiksel olarak anlamlı (p
Prognostic Value of Diffuse Cancer Inflammation Index (ALI), Serum Neutrophil/Lymphocyte Ratio (NLR) and Platelet/lymphocyte Ratio (PLR) in Advanced Stage Lung Cancer
Objective: Lung cancer (Ca) is the most common type of cancer that causes death worldwide. Systemic inflammation has been shown to play a role in cancer etiopathogenesis and can be activated from oncogenic changes in cancer cells. In lung cancer, although there are studies showing that systemic inflammatory parameters may have a role in determining prognosis and risky cases, the results are still controversial. In our study, the prognostic effects of inflammatory parameters calculated from serum were investigated in lung Ca. Method: One hundred fifteen patients with locally advanced and advanced lung cancer who were diagnosed in our chest diseases clinic between 2013 and 2015 were retrospectively analyzed. The relationship between advanced lung cancer inflammation index (ALI index), serum neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) levels at the time of diagnosis were calculated, and their relationship with overall survival (OS), disease-free survival (PFS) and the treatment response and their effect on predicting prognosis were investigated. Results: In our study, when advanced lung cancer cases were examined regarding OS; ALI, and NLR were statistically significant (p
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- ISSN: 1300-4115
- Başlangıç: 1986
- Yayıncı: Ali Cangül
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