Tuğba COŞGUN, Ferda AKSOY, Cemal Asım KUTLU

AKCİĞERİN NADİR GÖRÜLEN BİR MALİGNİTESİ: RABDOİD TÜMÖR

Rabdoid fenotipli büyük hücreli karsinomlar akciğerin nadir görülen tümörleridir. Akciğer kanserleri içinde Büyük Hücreli kanserlerin görülme sıklığı %10'dur (1). Büyük hücreli kanserlerin içinde ise; çok az oranda tümör Rhabdoid fenotip ile kendi gösterir. İlk olarak böbrek lokalizasyonlu tanımlanmıştır (2). Renal veya ekstra renal nadir görülen bu tümörler; klinik olarak agresif seyirli olması sebebiyle önemlidir. Bu olgu sunumuzda; pür rabdoid fenotipli akciğer büyük hücreli karsinomu tanısı alan, 52 yaşındaki bir erkek hastamızı sunuyoruz. Preoperatif dönemde yapılan tetkiklerde sol üst lobda lezyon saptanması üzerine operasyon kararı alınan hastamızın patoloji sonucu nadir görülen bir malignite olan rabdoid tümör olarak bildirildi. Akciğer rabdoid tümörü agresif seyirli bir malignite olduğu için hastamız sık aralıklarla takibe alınmıştır.

Anahtar Kelimeler:

Rabdoid tümör, Büyük Hücreli Kanser, Rabdoid fenotip

A RARE MALIGNANCY OF LUNG: RHABDOID TUMOR

Malign rhabdoid tumors are rare pulmonary tumors. The percent of Large Cell Carcinomas is 10 % of all lung cancers (1). In this group tumours with Rhabdoid phenotipics are less frequently. At first time it was defined for renal located tumours (2). This tumors are rarely renal or extra renal. But they have significant roles because of they are aggressive prognosis. In this case we reported a 52 years old male patient. We identified a lesion at left upper lobe, and we decided to operate him. This case is important because of it's postoperative pathology was reported as rhabdoid tumor which is a rare malignancy of lung. Because of ‘rhabdoid tumors' are agresive malignancies, we checked up him at frequent intevals.

Keywords:

Rhabdoid tumor, Large Cell Carcinoma, Rhabdoid phenotipic,

PDF

___

1. Travis WD, Travis LB, DeVesa SS. Lung Cancer. Cancer. 1995;75:191-202.
2. Beckwith JB, Palmer NF, Histopathology and prognosis of Wilms’ tumor: results from the first National Wilms’ Tumor Study. Cancer 1978; 41:1937-48.
3. Attia A, Suleman M, Mosleh H. Malignant rhabdoid tumor of the lung in the young adult: a case report Case reports in Pulmonology. 2011;2011:323584. Epub 2011 Oct 1.
4. 4.Haas J.E, Palmer N.F, WeinbergA.G, et al,’Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children.’ Human pathology, vol. 12, no. 7,pp.646-657, 1981
5. Colby TV, Koss MN, Travis WD. Carcinoid and other neuroendocrine tumors. In:Travis WD, editör. Tumors of Lower Respiratory tract. Washington DC: Armed Forces Institute of Pathology; 1995.p.311.
6. Tamboli P, Toprani TH, Amin MB, et al. Carcinoma of lung with rhabdoid features. Human Pathology. 2004 Jan; 35(1):8-13.
7. Saini G, Kumar M, Julka PK, Puri T, Sharma M, Rath GK. Rhabdoid variant of lung cancer: clinicopathological details of a case and a review of literature. Journal of cancer research and therapeutic 2009 Jan-Mar; 5(1):54-7.
8. Parham DM, Weeks DA, Beckwith JB. The clinicopathologic spectrum of putative extrarenal rhabdoid tumors: An analysis of 42 cases studied with immunohistochemistry or electron microscopy. Am J Surg Pathol 1994; 18:1010-29.
9. Dettmer M, Hench J, Pang B, Willi N, et al. Rhabdoid large cell carcinoma of lung, with illustrative immunohistochemical and molecular findings. Appl Immunohistochem Mol Morphol. 2012 May; 20(3):208-13.
10. Alberto M. Marchevsky MD Lung Malignancies and Special Pathologic Procedures. Medical Management of the Thoracic Surgery Patient. Part4, Chapter 22, 213-237.
11. Izquierdo-Garcia FM, Moreno-Mata N, HerranzAladro ML, Cañizares MA, Alvarez-Fernandez E. Histology and Histopathology. Lung carcinoma with rhabdoid component. A series of seven cases associated with uncommon types of nonsmall cell lung carcinomas and alveolar entrapment. 2010 Oct; 25(10): 1287-95.