ESİN OKTAY, Ozge KESKIN, M. Ferhat EYİLER, Özlem YERSAL, ÖZGÜR TANRIVERDİ, Erdinç NAYIR, GİZEM DÖNMEZ YALÇIN, NEZİH MEYDAN

WHICH HEMATOLOGIC PARAMETERS PREDICT SURVIVAL IN PATIENTS WITH SMALL CELL LUNG CANCER?

Introduction : Small cell lung cancer(SCLC) is the most aggressive form of lung cancer. Recent studies showed that inflammation plays an important role in carcinogenesis. In this study, we investigated the survival impact of pre-treatment multiple inflammatory and hematological blood parameters and their relation between each other in SCLC. Material and Method: This retrospective study enrolled 110 SCLC patients. The patients underwent platinumbased combination chemotherapy as a first-line treatment between 2012-2015. Untreated patients' hematological tests were taken into evaluation at initial diagnosis. Neutrophil, lymphocyte, platelet, hemoglobin (HGB), mean corpuscular volume (MCV), and mean platelet volume (MPV) values were collected. neutrophil-lymphocyte ratio (NLR)and the platelet-lymphocyte ratio (PLR), immune-inflammation index (SII) were calculated. Overall survival of patients (OS) was calculated until to January 2017. All analyses were conducted by SPSS v23.0 statistical software. Results: Favorable prognostic factors were found to be age ˂65 years, limited stage, presence of curative radyotherapy and good performans status. In univariate analysis showed that neutrophil-lymphocyte ratio (NLR)85 fl predicted better survival outcomes in extensive-stage SCLC patients. In our study; patients at extensive-stage with platelet-lymphocyte ratio(PLR)

KÜÇÜK HÜCRELİ AKCİĞER KANSERİ HASTALARINDA HANGİ HEMATOLOJİK PARAMETRELER YAŞAM SÜRESİNİN BELİRTEÇLERİDİR?

Giriş: Küçük hücreli akciğer kanseri(KHAK) akciğer kanserleri arasında en agresif türdür. İnflamasyonun bir çok kanser türünün gelişmesi ve progresyonunda kritik rol aldığı gösterilmiştir. Bu çalışmada KHAK’i hastalarında tedavi öncesi inflamasyon ile ilgili skorların ve hematolojik parametrelerin sağkalım için prognostik değeri incelenmiştir. Gereç ve Yöntem: KHAK’i tanılı 110 olgunun tedavi öncesi klinik ve hematolojik verileri retrospektif olarak incelendi. 2012-2015 yılları arasında birinci basamak tedavide platin bazlı kombinasyon kemoterapisi uygulanan hastaların tanı anında tedavi öncesi hematolojik testleri değerlendirildi. Nötrofil, lenfosit, trombosit, hemoglobin (HGB), ortalama korpusküler hacim (MCV) ve ortalama trombosit hacmi (MPV) değerleri toplandı. Nötrofil lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR), immün inflamasyon indeksi (SII) hesaplandı. Hastaların genel sağkalımı Ocak 2017'ye kadar hesaplandı. Tüm analizler SPSS v23.0 istatistik yazılımı ile yapıldı. Bulgular: Tüm hastalardaki yaşam süresi analizinde iyi prognostik kriter; ˂65 yaş, sınırlı evre, küratif radyoterapi varlığı ve iyi performans durumu olarak tesbit edildi. Tek değişkenli analizde yaygın evre KHAK hastalarında, nötrofil lenfosit oranı (NLR) 85 fl ise sağkalım sonuçlarının daha iyi olduğu gösterilmiştir. Çalışmamızda; trombosit-lenfosit oranı (PLR)

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