TİP 2 DİYABETİK HASTALARDA ORTALAMA TROMBOSİT VOLÜMÜ KARŞILAŞTIRILMASI VE MİKROVASKULER KOMPLİKASYONLARLA İLİŞKİSİNİN DEĞERLENDİRİLMESİ

Bu çalışmada; Tip2 diyabetik olguların ortalama trombosit hacmi ile glisemik kontrol ve mikrovasküler komplikasyonlarla ilişkisinin incelenmesi amaçlandı. 48 tip 2 diyabetik hasta 21 oral antidiyabetik ve 27 insülin kulanan birey çalışmaya alındı. 12 saat açlık sonrası MPV, lipid düzeyleri, HbA1c ve mikrovasküler komplikasyonlar açısından bireyler incelendi. Spearman korelasyonu ile MPV ve diğer çalışılan parametreler arasındaki ilişkiler değerlendirildi. Diyabetik hastalarda hem MPV ile HbA1c hem de MPV ve diyabetik komplikasyonlar açısından anlamlı bir ilişki bulunamadı. İnsülin kullanan bireylerde ortalama MPV düzeyi 8.9 ve oral antidiyabetik kullanan olgularda ise 8.1 olarak tespit edildi. MPV insülin kullananlarda oral antidiyabetik kullananlara göre daha yüksek olarak bulundu p=0.034 . Diyabetik komplikasyonları olan olgularda her ne kadar MPV düzeyleri komplikasyonu olmıyan bireylere göre daha yüksek bulunsa da bu istatiksel olarak anlamlı değildi. Diyabetik microvasküler komplikasyon gelişimi ile HbA1c ve hastalık süresinin ilişkisi mevcuttu p < 0.05 . Albuminüri retinopati ve nöropati gelişimi açısından aralarında bir korelasyonu mevcuttu p < 0.05 . Biz bu çalışmamızda, diyabetik komplikasyonlar ile ortalama trombosit volümü arasında bir ilişki tespit edemedik. MPV her ne kadar diyabetik komplikasyonu gelişimi açısından bir risk faktörü olduğunu tespit edemesekte patogenezinde rol alabileceğini düşünmekteyiz. Gelişen bir mikrovasküler komplikasyonun diğer komplikasyonların gelişimi açısından bir risk faktörü olduğunu gözlemlenmiştir

Anahtar Kelimeler:

İmmunglobulin, ortalama trombosit volümü, diyabetik komplikasyonlar

COMPARISON OF MEAN PLATELET VOLUME IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND THE RELATIONSHİP BETWEEN MICROVASCULAR COMPLICATIONS

The aim of this study was to investigate the relationship among mean platelet volume MPV , glycemic control, and microvascular complications in type 2 DM. Forty eight patients with type 2 DM 21 oral antidiabetic and 27 insulin users individuals were enrolled in the study. After 12 hours of fasting, we examined their MPV, lipid profile, HbA1c and also evaluated microvascular complications. We applied Spearman correlation test on the data for defining the relation between MPV and other parametres. In diabetic patients, there was no significant positive correlation between both MPV and HbA1c levels or MPV and diabetic vascular complications. Mean MPV in the insulin users group was 8.9 fl, and in the oral antidiabetic group 8.1 fl. MPV was significantly higher in patients with insulin users than in oral antidiabetic group p=0.034 . However mean MPV was higher in diabetic microvascular complications; this was not reach statically significant. Diabetic microvascular complications were positively correlated with HbA1c and disease duration p < 0.05 . Albuminuria was significantly correlated with retinopathy and neuropathy development p < 0.05 . We could not determine a correlation between diabetic complications and platelet volumes. We suggest that MPV may be not a risk factor for development diabetic complications; however it may have a role in the pathogenesis. One diabetic complication may be influences the risk of developing other microvascular complications

Keywords:

Immunoglobulin, mean platelet volume, diabetic complications,

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