Koyunlarda döl verimini ve ovulasyon oranını etkileyen BMP-1B, BMP-15 ve GDF-9 genlerindeki mutasyonlar

Koyunlar 900 farklı ırka sahip oldukları için ovulasyon oranı ve doğurganlık gibi fizyolojik özellikleri büyük çeşitlilik göstermektedir. Koyunların ovulasyon sayısındaki farklılıklar bir grup genin etkisi altındadır. Yapılan çalışmalar sonucunda koyunlardaki döl verimi üzerine etkili transforming growth factor beta (TGFp) süper ailesinden iki adet yapısal gen ve bir TGFp reseptör geni tespit edilmiş ve sırasıyla BMP- reseptör IB (BMP-IB) geni, kemik morfogenetik protein geni (bone morphogenetic protein) (BMP-15) ve büyüme ayrımlaşma faktörü 9b (growth differentiation factor) (GDF-9) geni olarak isimlendirilmişlerdir. Bu makalenin amacı koyunlarda ovulasyon oranı ve döl verimi etkileyen BMP-IB, BMP-15 ve GDF-9 gen mutasyonları ile ilgili bilgileri derlemektir.

Mutations in BMP-1B, BMP-15 and GDF-9 genes and their effets on fecundity and ovulation rate in sheep

Sheep have more than 900 different breeds. Therefore their phsiological characteristics including ovulation rate and fecundity, vary greatly. A group of genes effect the ovulation rates of sheep. Studies showed that there are two structural genes and one receptor gene that are the members of the transforming growth factor beta TGFfS family and their names are BMP-IB, BMP-15 and GDF-9 respectively. In this article we focus on to review the data of the BMP-IB, BMP-15 ve GDF-9 gene mutations that effect sheep's ovulation rate and fecundity

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