A case of polycystic kidney disease in a persian cat

Polikistik Böbrek Hastalığı (PBH); otozomal dominant bir gen tarafından oluşturulan ve özellikle İran kedileri ile egzotik kedilerde görülen, kalıtsal bir hastalıktır. Sporadik olarak görülen hastalık böbrek yetmezliği gelişene kadar asemptomatik seyreder. Hastalığın tanısı en erken 7 haftalık iken yapılan abdomen ultrasonografısi ve DNA testi ile konulabilir. Olgumuzu karın bölgesinde bilateral şişkinlik, kilo kaybı, poliüri, polidipsi ve letarji şikayetleriyle İstanbul Üniversitesi Veteriner Fakültesi İç Hastalıklar Kliniği'ne getirilen 7 yaşında erkek bir İran kedisi oluşturdu. Rutin genel muayenesinde vücut ısısı normal olmasına karşın halsiz olduğu gözlenen hastanın her iki böbreğinin de normal konturlarmı kaybettiği ve aşırı büyümüş olduğu saptandı. Abdomenin ultrasonogram muayenesinde her iki böbreğin de büyüdüğü, ve her böbrekte de kor- teks ve medulladan köken alan ve çaplan 2-15 mm arasında değişen, çok sayıda kistin bulunduğu izlendi. Yaşam kalitesini düzeltmek amacıyla medikal tedavisi düzenlenen hasta 36 gün sonra hayatını kaybetti.

Bir İran kedisinde polikistik böbrek hastalığı olgusu

Feline polycystic kidney disease (PKD) is an inherited autosomal dominant disease that has been identified in Persian cats and Persian related breeds such as the Exotic Shorthair cats. PKD has been reported sporadically in the veterinary literature and progress as- ymptomaticly until the renal deficiency is observed. Diagnosis of the PKD can be carried out by abdominal ultrasonography and DNA test in 7 weeks old. Our case was a 7 years old male Persian cat which had been brought to Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University with complaints such as weight loss, polydipsia, polyuria, lethargy and bilateral enlargement of abdomen. Although the body temprature and outline of the kidneys were normal in physical examination, the cat was lathergic and both of the kidneys was enlarged. At the result of ultrasonographic evaluation, the enlargement of the both kidneys were observed and numerous cysts were determined which were originated from both medulla and cortex of the kidneys and their diameters were changed between 2-15 mm. Although a medical therapy protocol had carried out for the purpose of increasing the quality of his life, the patient was died of 36th day of the treatment.

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  • 1. Battershell, D., Garcia, J.P.: Polycystic Kidney in a Cat, Journal of the American Veterinary Medical Association, 1969; 154: 665-666.
  • 2. Biller, D.S., DiBartola, S.P., Eaton, K.A., Pflueger, S., Well, M.L.: Inheritance of Polycystic Kidney Disease In Persian Cats, Journal of Heredity, 1996; 87: 1-5.
  • 3. Beck, C., Lavelle, R.B.: Feline Polycystic Kidney Disease in Persian Cats; A Prospective Study Using Ultrasonography, Aust. Vet. J., March 2001; Vol 79, No. 3.
  • 4. Leslie A. Lyons, Feline Tests, Erişim 26/05/2009, Department of Population Health and Reproduction, University of California Davis, http://www.vgl.ucdavis.edu/services/cat.php
  • 5. Bonazzi M.: Prevalence of the Polycystic Kidney Disease and Renal and Urinary Bladder Ultrasonographic Abnormalities in Persian and Exotic Shorthair Cats in Italy. Journal of Feline Medicine and Surgery, 2007; 9: 387-391.
  • 6. Barthez, P.Y., Rivier, P., Begon, D.: Prevalence of polycystic kidney disease in Persian and Persian related cats in France . Journal of Feline Medicine and Surgery, 2003; 5: 345-347.
  • 7. Barrs, V.R., Gunew, M., Foster, S.F., Beatty, J.A., Malik R.: Prevalence of Autosomal Dominant Polycystic Kidney Disease in Persian Cats and Related-Breeds in Sydney and Brisbane, Aust Vet J, April 2001; Vol 79, No: 4.
  • 8. Rawlings C.A., Bjorling D.E., Christie B.A.: Kidneys. In: Textbook of Small Animal Surgery, Ed. Slatter D. Saunders Company, 2003: 1607.
  • 9. Biller DS et al: Inheritance of Polycystic Kidney Disease in Persian Cats. J Heredity, 1996; 87: 1-5.
  • 10. Pedersen KM et al: Increased mean arterial pressure and Aldosterone-to-renin Ratio in Persian Cats with Polycystic Kidney Disease. J Vet Intern Med, 2003, 17: 21-27.
  • 11. Miller RH et al: Effect of Enalapril on Blood Pressure, Renal Function, and the Renin- Angiotensin-Aldosterone System in Cats with Autosomal Dominant Polycystic Kidney Disease. Am J Vet Res, 1999; 60: 1516-1525.
  • 12. Cannon MJ et al: Prevalence of Polycystic Kidney Disease in Persian Cats in the United Kingdom. Vet Ree, 2001; 149: 409-411.
  • 13. Barrs VR et al: Prevalence of Autosomal Dominant Polycystic Kidney Disease in Persian Cats and Related Breeds in Sydney and Brisbane. Aust Vet J., 2001; 79: 257-259.
  • 14. Stebbins KE: Polycystic Disease of the Kidney and Liver in an Adult Persian Cat. J Comp Pathol, 1989; 100: 327-330.
  • 15. Bosje JT, van den Ingh TS, van der Linde-Sipman JS: Polycystic Kidney and Liver Disease in Cats. Vet Q, 1998; 20: 136-139.