Detection of Neutralising Antibody Titration in Vaccinated Owned and Stray Dogs against Rabies Virus

Bu çalışmada, İstanbul İli sınırları içerisinde yaşayan, aşılanmış sahipli ve sahipsiz beşyüz köpekte kuduz virusuna karşı oluşmuş nötralizan antikor seviyelerinin saptanması amaçlandı. Kan serumlarında oluşmuş nötralizan antikor titreleri ELISA ile araştırıldı. İncelenen köpeklerin 65 tanesi (%13) yeterli düzeyde nötralizan antikor (0,5 IU/ml ve üzeri) titresine sahipti. Ayrıca aşılamayı takiben oluşmuş nötralizan antikor seviyelerine sahiplilik durumu, aşı tekrar sayısı, yaş, yaşam alanı, cinsiyet, son aşı ile örnekleme arası geçen süre gibi faktörlerin etkileri istatistiksel değerlendirme ile incelendi. İstatistiksel değerlendirmeler sonucunda, son aşı ile örnekleme arası geçen sürenin şekillenmiş nötralizan antikor titrelerine etkisinin önemli olduğu (P

Aşılanmış Sahipli Ve Sahipsiz Köpeklerde Kuduz Virusuna Karşı Oluşmuş Nötralizan Antikor Seviyelerinin Saptanması

The aim of this study was to determine the titers of neutralising antibodies against rabies virus in five hundred vaccinated owned and stray dogs within the Istanbul province. The levels of the neutralising antibody titration in the blood serum were evaluated by Enzyme-Linked Immunosorbent Assay (ELISA) method. Sixty five (13%) of the dogs examined had adequate level (0.5 IU/ml and over) of antibody titration. Also, the effects on the formation of the neutralising antibody levels following the vaccination of some factors, such as being owned or stray, the number of repetition of vaccination, the age, living area, sex, interval between the last vaccination and sampling, have been evaluated statistically. As a result of the statistical evaluations, it has been determined that interval between the last vaccination and sampling had an important effect on formation of the neutralising antibody titration (P

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