Mehmet Mahir FERSAHOĞLU, Ahmet ÇAKMAK, Hüseyin ÇİYİLTEPE, Nuriye ESEN BULUT, Ayşe Tuba FERSAHOĞLU, Aziz Bora KARİP, Anıl ERGİN, Ali Cihan BİLGİLİ, Kemal MEMİŞOĞLU

SLEEVE GASTREKTOMİ SONRASI FARKLI DOZLARDA URSODEOKSİKOLİK ASİT KULLANIMININ SAFRA TAŞI OLUŞUMUNA ETKİSİ

Amaç: Laparoskopik Sleeve Gastrektomi (LSG) sonrası safra taşlarının önlenmesinde altı ay boyunca farklı dozlarda ursodeoxycholic acid (UDCA) kullanımının 6. ve 12. aylarda safra taşı oluşumuna etkilerini değerlendirmek. Gereç ve Yöntem: Morbid obezite nedeniyle LSG uygulanan hastaların verileri analiz edildi. 20’şer kişilik üç grup oluşturuldu: Kontrol grubu; LSG sonrası altı ay süreyle UCDA 500 mg/gün ile tedavi edilen Grup I; LSG sonrası altı ay süreyle UCDA 1000 mg/ gün ile tedavi edilen Grup II. Demografik özellikler, eşlik eden hastalıklar, ameliyat öncesi ve sonrası kolesterol ve trigliserit farklılıkları, aşırı kilo kaybı (%EWL), toplam kilo kaybı (%TWL), vücut kitle indeksi (BMI) ve abdominal ultrason (US) verileri ameliyat öncesi ve ameliyattan altı ve 12 ay sonra kolelitiazis (CL) gelişimi değerlendirildi. Bulgular: Olguların 6. ay sonuçlarında kontrol grubunun US sonuçlarında taş tespit oranı Grup II’ye göre anlamlı olarak yüksek bulundu (p=0,001; p<0,01). Kontrol grubu ile Grup I arasında (p=0,149), Grup I ile Grup II arasında (p=0,066) istatistiksel olarak anlamlı fark yoktu. Olguların 12. ay sonuçlarında kontrol grubunun US sonuçlarında taş tespit oranı Grup I ve Grup II’ye göre anlamlı olarak yüksek bulundu (p=0,010; p<0,05). Grup I ve Grup II arasında istatistiksel olarak anlamlı fark yoktu. Sonuç: Bu çalışma sonucunda hastalara LSG sonrası 1000 mg/ gün UDCA verilmesini öneriyoruz.

Anahtar Kelimeler:

Kolelitiazis, laparoskopik sleeve gastrektomi, ursodeoksikolik asit

THE EFFECT OF USE OF DIFFERENT DOSES OF URSODEOXYCOLIC ACID ON GALLSTONE FORMATION AFTER SLEEVE GASTRECTOMY

Objective: To evaluate the effects of using different doses of ursodeoxycholic acid (UDCA) for six months in prevention of gallstones after Laparoscopic Sleeve Gastrectomy (LSG) on the formation of gallstones in the 6th and 12th months. Materials and Methods: The data of patients who underwent LSG for morbid obesity were analyzed. Three groups of 20 people were formed. These were the control group, Group I who were treated with UCDA 500 mg/day for six months after LSG, and Group II who were treated with UCDA 1000 mg/day for 6 months after LSG. Demographic characteristics, co-morbid diseases, cholesterol and triglyceride differences before and after surgery, excess weight loss (EWL%), total weight loss (TWL%), body mass index (BMI), and abdominal ultrasound (US) data for the occurrence of cholelithiasis (CL) preoperatively and at six and 12 months after surgery were collected. Results: The results of tests taken on these patients in the sixth month revealed that the stone detection rate in the US results of the control group was significantly higher than that in Group II (p=0.001; p<0.01). There was no statistically significant difference between the control group and Group I (p=0.149), and between Group I and Group II (p=0.066). The results of tests taken in the 12th month showed that the stone detection rate in the US results of the control group was significantly higher than Group I and Group II (p=0.010; p<0.05). There was no statistically significant difference between Group I and Group II. Conclusion: As a result of this study, we recommend that patients be given 1000 mg/day UDCA after LSG.

Keywords:

Cholelithiasis, laparoscopic sleeve gastrectomy, ursodeoxycholic acid,

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