Gülseren AKTAŞ, Ali AĞAÇFİDAN, Gülden YILMAZ, Selim BADUR, Ahmet UYANIKOĞLU, Ahmet DANALIOĞLU, At ALL.

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SİFİLİZ SEROLOJİSİ POZİTİF HASTALARDA 'HIV' SEROPREVALANSI

Amaç: Sifiliz serolojisi pozitif sonuç veren hastalarda ‘Human Immunodeficiency Virus’ (HIV) seroprevalansının araştırılmasıdır. Gereç ve yöntem: ‘Rapid plasma reagin’ (RPR) ve/veya ‘Treponema pallidum hemagglutination assay’ (TPHA) testleri ile pozitif sonuç vermiş 105 (%8,4) serum örneği, HIV-1/2 hızlı test (INSTI HIV1/HIV2 Antibody Test, Bartel Inc. USA) ile test edilmiş, pozitif sonuç veren serumlar ile ‘enzyme linked immuno-sorbent assay’ (ELISA) ve doğrulama testi olarak ‘western blot’ (WB) testleri yapılmıştır. Pozitif sonuç veren örnekler treponemal testler olan ‘Serodia Treponema pallidum particle agglutination’(TP.PA) (Serodia-TP.PA, Fujirebio Inc., Japan); ‘Murex Syphilis ICE’ (ICE), IgG+IgM (ELISA), (ICE Syphilis Detection Pack, Murex Biotech Limited, Dartford, UK); ‘Enzywell TP’(TP), IgG+M (ELISA) (Diesse, Sienna, Italy); ‘Captia Syphilis-M’(CS-M) (IgM) (ELISA) (CaptiaTMSyphilis-M, Trinity Biotech plc, Ireland) ve ‘fluorescent treponemal antibody absorption assay’ (FTA-abs) (MastaflourTM-FTA-ABS, Mast Diagnostics, UK) ile de test edilmiştir. Bulgular: RPR testi pozitif ve TPHA negatif sonuç veren iki örnekte anti-HIV hem ELISA hem de WB testleri ile pozitif olarak saptanmıştır. Bu serumlar ile ayrıca yapılan TP.PA, ICE, TP, CS-M ve FTA-abs testleri de negatif sonuç vermiştir ve RPR ile elde edilen pozitif sonuçlar, biyolojik yalancı pozitif (BYP-BFP) reaksiyon olarak değerlendirilmişlerdir. Sifiliz serolojisi pozitif olan hiçbir serum örneğinde anti-HIV antikorları saptanmamıştır. Sonuç: Seksüel yolla bulaşan hastalığa (STD) sahip hastalar, aynı yolla bulaşan HIV infeksiyonunu kazanma riskini taşıdıkları için sifiliz serolojisi pozitif hastalar HIV riski yönünden araştırılmalıdır.
Anahtar Kelimeler:

Sifiliz serolojisi, HIV seroprevalansı, BYP-BFP reaksiyon

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İstanbul Tıp Fakültesi Dergisi-Cover
  • Başlangıç: 1916
  • Yayıncı: İstanbul Üniversitesi Yayınevi
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