Esra BİLİR, Emine Elif VATANOĞLU LUTZ, Ayşe Arzu AKALIN

PLAZMA TEDAVİSİNİN TARİHİ: COVID-19 ENFEKSİYONU İÇİN GÜNÜMÜZDE KULLANILMAKTA OLAN BİR TEDAVİ SEÇENEĞİ

İçinde bulunduğumuz mevcut pandemide “Severe Acute Respiratory Syndrome Coronavirus-2” (SARS-CoV-2) virüsünün neden olduğu yeni koronavirüs hastalığı (COVID-19) için aşı geliştirme çalışmaları devam ederken, konvalesan plazma tedavisi de etkili bir tedavi yöntemi olarak bir fırsat sunmaktadır. Bu pandemide, şiddetli ve kritik COVID-19 hastaları için etkili acil tedavilere ihtiyaç duyulmakta, hem temel hem de klinik araştırmalar benzeri görülmemiş bir hızda devam etmekte ve bir çok çalışma konvalesan plazma tedavisine yönlendirmektedir. Konvalesan plazma tedavisi, 1900’lerden beri bilinen ve o zamandan beri çeşitli hastalıklarda kullanılan bir tedavi seçeneğidir. Konvalesan plazma tedavisi halihazırda COVID-19 tanılı hastaların tedavisinde kullanılan tedavi seçeneklerinden birisidir. Yakın geçmişte dünyayı etkisi altına alan MERS, SARS ve Ebola salgınlarında da bu tedavi yönteminin uygulandığını görmekteyiz. Bu derlemede konvalesan plazma tedavisinin tarihçesine ve bu hayati buluşun arkasındaki bilim insanlarına genel bir bakış atmayı amaçlıyoruz. İkincil olarak, COVID-19’un tedavisinde dünyadaki plazma kullanımındaki küresel gelişmeleri sunmak hedeflendi.

Anahtar Kelimeler:

COVID-19, konvalesent plazma tedavisi, tarihçe

HISTORY OF PLASMA THERAPY: A CURRENTLY USED TREATMENT OPTION FOR COVID-19

The current pandemic provides the most incredible opportunity to develop convalescent plasma therapy into an effective treatment modality for the coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) while a vaccine is still under development. The global reach of this pandemic, and the immediate need for effective treatments for patients with severe and critical COVID-19, is driving both basic and clinical research at an unprecedented rate. Convalescent plasma therapy is a treatment option that has been known since the 1900s and has been used in various disease treatments since then. Convalescent plasma therapy is one of the treatments currently being used in the treatment of patients with COVID-19. We see that this treatment method was likewise used in MERS, SARS, and Ebola epidemics, which occurred worldwide in the recent past. This review aims to provide an overview of plasma therapy’s history and the scientists behind this vital discovery. Secondarily, we report the recent global advances in convalescent plasma use in COVID-19 treatment.

Keywords:

COVID-19, convalescent plasma therapy, history,

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