A.c. Ekinci, G. Baktir G. SUNAM, O. ÖZDEMİR

THE EFFECT OF CYPROHEPTADINE AND AMANTADINE ON NEUROLEPTIC-INDUCED CATALEPSY IN THE RAT

Katalepsi bir tek nedene bagh OW ortaya qllian bit durum degildir. Biyokimyasal ve norotransmitter sistemler agsmdan bu davran~gln sebebi, katalepsi olughYan qegitli maddeler iqin fad&&. Omegin noroleptiklerin kataleptojenik etkisi striatal dopamin reseptorlerinin blokaj~na bajjlanmqtx. Niirofizyolojik ve biyokimyasal veriler dopamine jik nigro-striatal sistemin duzenli $&$masmda gma-aminobutirik asid ve serotonin'e bagh olan bir mekanizmmn etkili oldugunu gostermigtir. Bir serotonin antagonisti olan siproheptadin'in ve Parkinson sendromunun tedavisinde hdlanllan amantadin'in; fenotiazin bilegigi olan trifluperazin ve noroIeptik olarak hullmlan ve etkili bir ih olan pimozid'in yaphklan katalepsiye etkilerini inceledik. Si- $anlara onceden siproheptadin verildiginde yukar~da belirtilen ila~lann neden oldugu katalepsinin giddetinin azal&@ goriildii. Diger yandan s~qanlara onceden amantadin verildigi zaman, ayni nijroleptik ilaglann ortaya @ar&gi katalepsinin de gec; ortaya qkhg~ gozlendi. Cahgmamum sonuqlan yukanda belirtilen noroleptik ilaqlann neden oldugu katalepside, serotonerjik ve dopaminerjik sistemlere etkili olan siproheptadin ve amantadinin de rolii oldu~mu gostermektedir.

Anahtar Kelimeler:

Catalepsy, neuroleptic, cyproheptadine, amantadine

THE EFFECT OF CYPROHEPTADINE AND AMANTADINE ON NEUROLEPTIC-INDUCED CATALEPSY IN THE RAT

Catalepsy is not a unitary phenomenon. With respect to biochemical mechanisms and neurotransmitter sytems, the origin of this behavioural response varies according to different substances which cause catalepsy. For example, the catdeptogenic effect of neuroleptics has been related to the blockage of striatal doparnine receptors. Neurophysiological and biochemical data have shown that a mechanism caused by gama-aminobutyric acid and serotonin have been effective in the proper functioning of the dopaminergic nigrosbriatal tract. We have studied the effects of cyproheptadine, a serotonin antagonist, and of amantadin which is used in the treatment of Parkinson syndrome on the catalepsy induced by trifluoperazine, a phenothiazin compound, and pimozid, a drug used as a neuroleptic. It was observed that when rats were pretreated with cyproheptadine as well as amantadine, the catalepsy induced by the above neuroleptic drugs was attenuated. The results of our study show that substances which have an effect on the serotonergic and dopaminergic systems also play a role on cases of catalepsy induced by the neuroleptic drugs mentioned above.

Keywords:

Catalepsy, neuroleptic, cyproheptadine, amantadine,

PDF

___

1. Van Rossum, J. M.,Arclz. Int. Plzarmacodyn., 160,492 (1966).
2. Nyback, H., Schubert, J., SedvaU, G., J. Pharnl. Plzarmacol., 22, 632 (1970).
3. Anden, N. E., Ross, B-E., Verdinius, B., LifeSci., 3,149 (1964).
4. Balsara, J. J. et al., J. Plzarnz. Plmrmacol., 31,255 (1979).
5. Ahtee, L., ibid., 25,649 (1973).
6. Boyaner, H. G., Radouco- Thomas, S., ibid., 23,974 (1971).
7. Wilcox, R. E., Lewitt, R. A., Pharmac. Bioclzem. Bellav., 9,425 (1978).
8. Hicks, P. B., LifeSci., 47,1609 (1990).
9. Balsara, J. J., Jadhav, J. H., Chandorkar, A. G., Psyc/wplzarnzacology, 68, 105 (1980).
10. Broekkamp, C. L. E. et al., Narinyn-Sclzmiedeberg's Arch. Plmrmacol., 338,191 (1988).
11. Davies, J. A., Williams, J., Brit. J. Pharmacol., 78, 137 (1983).
12. Williams, J., Davies, J. A., J. Pllarm., Plzarmacol., 35,734 (1983).
13. Simon, P., Malatray, J., Boissier, J. R., ibid., 22,547 (1970).
14. Maj, J., Sarnek, J., Klimek, W., Abstracfs of tlze Sixth International Congress of Plzarmacology, 352, Pergamon Press, 1977