DISSOLUTION RATE OF NALIDIXlC ACID-AVICEL GROUND MIXTURES

Nalidiksik asit idrar yollan enfeksiyonlannda kullandan antibakteriyel bir ilaqtx. Bu qahgmanin amacl nalidiksik asidin degigik ogiitilmiig kang~mlannm qoziinme h~zm~ ne olqiide arttxdlgm~ bulmaktx. Ogiitiilmiig kangunlar % 5,25,50,75 ve 95 oranlannda Avicel ilavesi ile hazlrlanh. Her bir konsantrasyondaki liang~m 10, 30,60 ve 120 dakikallk siirelerle bilyal~ degimende ogiitiildii, % 5'lik bgm ilaveten 150, 180 ve 210 dakika siirelerle ogiitiildii. Ogiitiilmii~ kan~mlar ayn1 oranlarda hazlrlanan fiziksel karl$~mlar ile hgdagtudd~. Coziinme hlzlmn gene1 olarak hem fiziksel lcangmlardan, hem de saf maddeden yiiksek oldugu saptan&. En yiiksek qoziinme h~zlan gu konsantrasyon/ogiitrne siiresi kombinasyonlan ile elde edildi. % 95-10', % 75-60', % 50-120', % 25-120' ve % 5-180'. 1 I IR spektroskopi, x-qm difrslktometri ve diferansiyel termal analiz yontemleri ile fiziksel ve ogiitiilmiig kan$imlann hyasal ve kristal-amorf ozellikleri a.rqtml&, ayn1 olduklan goriildii. Sonut; olarak, Avicel ile ogiitiilmiig kansmlar hazlrlamanm nali&ik asit qoziinme ~IZ~I arthrmada etkili bir yontem oldugu saptan&.

Anahtar Kelimeler:

Dissolution rate, nalidixic acid, Avicel, ground mizture

DISSOLUTION RATE OF NALIDIXlC ACID-AVICEL GROUND MIXTURES

Nalidixic acid is an antibacterial agent used for the treatment of urinary tract infections. The aim of this work was to examine the degree to which various ground mixtures of nalidixic acid enhanced its dissolution rate. Ground mixtures were prepared with Avicel, using Avicel concentmtions of 525, 50.75 and 95 %. Each concentration was ground for 10,30,60 and 120 minute periods and the 5 % mixture was ground for additional 150. 180 and 210 minute periods in n ball miII. The ground mixtures were compared to the physical mixtures of tile same Avicel concentrations. It was found that the dissolution rates were generally higher than for those of both physical mixtures and the pure acid.

Keywords:

Dissolution rate, nalidixic acid, Avicel, ground mizture,

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