Farklı Dozlarda Intraperitoneal 5-Fluorouracil Kullanımının Deneysel Intestinal Anastomozların İyileşme Süresi Üzerine Etkileri

Amaç: Kolorektal cerrahinin en önemli komplikasyonu anastomoz ayrılması veya kaçaktır. Lokal ve sistemik pek çok faktörün kolon anastomozlarının iyileşme sürecinde ve anastomoz kaçaklarının oluşmasında etkili olduğu bilinmektedir. Bu faktörlerden bir tanesi de kemoterapidir. Gastrointestinal sistem kanserlerinde başarılı sonuçlar alabilmek için cerrahi yöntem ile kemoterapi ve radyoterapi arasındaki hassas dengeyi bulabilmek şarttır.

Anahtar Kelimeler:

5-Florourasil, anastomoz, bölgesel perfüzyon kanser kemoterapisi

The Effects of Intraperitoneal 5-Fluorouracil Use at Different Doses on the Recovery Time of Experimental Intestinal Anastomoses

Aim: The most important complication of colorectal surgery is the separation of anastomosis or leakage. It is known that many local and systemic factors are effective in the healing process of colon anastomoses and in the formation of anastomotic leaks. One of these factors is chemotherapy. In order to achieve successful results in gastrointestinal system cancers, it is necessary to find the sensitive balance between the surgical method and chemotherapy and radiotherapy.

Keywords:

5-Fluorouracil, anastomosis, regional perfusion cancer chemotherapy,

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