Pimpinella species (Anise): Traditional use, Mineral, Nutrient and Chemical contents, Biological activities

Pimpinella species (Anise): Traditional use, Mineral, Nutrient and Chemical contents, Biological activities

Objective: Plants, which are natural materials of great importance to humans, are currently utilised for various purposes. The utilisation of plants with nourishing properties for the treatment of diseases has a long history. Material-Method: In this study, the general characteristics, usage areas, mineral and nutrient contents, biological activities, and chemical compositions of Pimpinella species reported in the literature have been compiled. The literature review reveals that the plant is widely used in traditional medicine. Results: Furthermore, it has been determined that they may serve as significant natural resources in terms of their mineral, nutritional, and chemical content. Furthermore, it has been observed based on reported data in the literature that Pimpinella species exhibit high levels of antioxidant and antimicrobial activity. Conclusion: Within this context, it has been observed that Pimpinella species can be significant sources not only in terms of their nutritional properties but also from a medicinal perspective.


  • 1. Mohammed FS, Sevindik M, Uysal I, Sevindik E, Akgül H. A Natural Material for Suppressing the effects of oxidative stress: biological activities of Alcea kurdica. Biol Bull. 2022; 49(Suppl 2): S59-S66.
  • 2. Sevindik M, Akgul H, Pehlivan M, Selamoglu, Z. Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresen Environ Bull. 2017;26(7):4757-4763.
  • 3. Mohammed FS, Günal S, Şabik AE, Akgül H, Sevindik M. Antioxidant and Antimicrobial activity of Scorzonera papposa collected from Iraq and Turkey. KSÜ Tar Doga Derg. 2020a;23(5): 1114-1118.
  • 4. Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H. Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi Univ J Sci. 2020b;33(4): 670-677.
  • 5. Korkmaz N, Dayangaç A, Sevindik M. Antioxidant, antimicrobial and antiproliferative activities of Galium aparine. J Fac Pharm Ankara. 2021;45(3): 554-564.
  • 6. Tewtrakul S, Subhadhirasakul S. Anti-allergic activity of some selected plants in the Zingiberaceae family. J Ethnopharmacol. 2007;109(3): 535-538.
  • 7. Hassan A, Rahman S, Deeba F, Mahmud S. Antimicrobial activity of some plant extracts having hepatoprotective effects. J Med Plant Res. 2009;3(1): 20-023.
  • 8. Yasin ZA, Ibrahim F, Rashid NN, Razif MF, Yusof R. The importance of some plant extracts as skin anti-aging resources: a review. Curr Pharm Biotechnol. 2017;18(11): 864-876.
  • 9. Mohammed FS, Akgul H, Sevindik M, Khaled BMT. Phenolic content and biological activities of Rhus coriaria var. zebaria. Fresen Environ Bull. 2018;27(8): 5694-5702.
  • 10. Mohammed FS, Karakaş M, Akgül H, Sevindik M. Medicinal properties of Allium calocephalum collected from Gara Mountain (Iraq). Fresen Environ Bull. 2019;28(10):7419-7426.
  • 11. Mohammed FS, Pehlivan M, Sevindik E, Akgul H, Sevindik M, Bozgeyik I, Yumrutas O. Pharmacological properties of edible Asparagus acutifolius and Asparagus officinalis collected from North Iraq and Turkey (Hatay). Acta Aliment. 2021a;50(1): 136-143.
  • 12. Unal O, Eraslan EC, Uysal I, Mohammed FS, Sevindik M, Akgul H. Biological activities and phenolic contents of Rumex scutatus collected from Turkey. Fresen Environ Bull. 2022;31(7):7341-7346.
  • 13. Uysal I, Koçer O, Mohammed FS, Lekesiz Ö, Doğan M, Şabik AE, Sevindik E, Gerçeker FO, Sevindik M. Pharmacological and Nutritional Properties: Genus Salvia. Adv Pharmacol. 2023;11(2): 140-155
  • 14. Pimenov MG, Leonov MV. The Asian Umbelliferae biodiversity database (ASIUM) with particular reference to South-West Asian taxa. Turkish J. Bot. 2004; 28(1): 139-145.
  • 15. Pu FT, Watson MF. Pimpinella L. Flora of China, 2005;14: 93-104.
  • 16. Spalik K, Downie SR. Intercontinental disjunctions in Cryptotaenia (Apiaceae, Oenantheae): an appraisal using molecular data. J Biogeogr. 2007;34(12): 2039-2054.
  • 17. Magee AR, van Wyk BE, Tilney PM, Downie SR. Phylogenetic position of African and Malagasy Pimpinella species and related genera (Apiaceae, Pimpinelleae). Plant Syst. Evol. 2010;288(3): 201-211.
  • 18. Fernández-Prieto JA, Sanna M, Bueno Sánchez Á, Molero-Mesa J, Llorens García L, Cires E. Polyphyletic origin in Pimpinella (Apiaceae): evidence in Western Europe. J. Plant Res. 2018;131(5): 747-758.
  • 19. AbouZid SF, Mohamed AA. Survey on medicinal plants and spices used in Beni-Sueif, Upper Egypt. J Ethnobiol Ethnomedicine 2011;7(1): 1-6.
  • 20. Hammer K, Laghetti G, Cifarelli S, Spahillari M, Perrino P. Pimpinella anisoides Briganti. Genet. Resour. Crop Evol. 2000;47(2): 223-225.
  • 21. Kreydiyyeh SI, Usta J, Knio K, Markossian S, Dagher S. Aniseed oil increases glucose absorption and reduces urine output in the rat. Life Sci. 2003;74(5): 663-673.
  • 22. Yöney A, Prieto JM, Lardos A, Heinrich M. Ethnopharmacy of turkish‐speaking cypriots in greater London. Phytother Res. 2010; 24(5): 731-740.
  • 23. Kang Y, Luczaj L, Ye S, Zhang S, Kang J. Wild food plants and wild edible fungi of Heihe valley (Qinling Mountains, Shaanxi, central China): herbophilia and indifference to fruits and mushrooms. Acta Soc Bot Pol. 2012;81(4): 405-413.
  • 24. Tetik F, Civelek S, Cakilcioglu U. Traditional uses of some medicinal plants in Malatya (Turkey). J Ethnopharmacol. 2013;146(1): 331-346.
  • 25. Tepe AS, Tepe B. Traditional use, biological activity potential and toxicity of Pimpinella species. Ind Crops Prod. 2015; 69: 153-166.
  • 26. Sun W, Shahrajabian MH, Cheng Q. Anise (Pimpinella anisum L.), a dominant spice and traditional medicinal herb for both food and medicinal purposes. Cogent Biol. 2019;5(1): 1673688.
  • 27. Mohammed FS, Korkmaz N, Doğan M, Şabik AE, Sevindik M. Some medicinal properties of Glycyrrhiza glabra (Licorice). J Fac Pharm Ankara. 2021b;45(3): 524-534.
  • 28. Ciftci M, Guler T, Dalkiliç B, Ertas ON. The effect of anise oil (Pimpinella anisum L.) on broiler performance. Int J Poult Sci. 2005;4(11): 851-855.
  • 29. Lee JJ, Choo MH, Lee MY. Physicochemical compositions of Pimpinella brachycarpa. J Korean Soc Food Sci Nutr. 2007;36(3): 327-331.
  • 30. Chae HS, Lee SH, Jeong HS, Kim WJ. Antioxidant activity and physicochemical characteristics of Pimpinella brachycarpa Nakai with treatments methods. Korean J Food Nutr. 2013;26(1): 125-131.
  • 31. Hassan FAS, Ali EFA. Comparative Study between Traditional Mineral Nutrition and Alternative Sources on Anise Plant Eur J Sci Res. 2013;106(2): 201-212.
  • 32. Abbasi AM, Xinbo-Guo X. Proximate composition, phenolic contents and in vitro antioxidant properties of Pimpinella stewartii (A wild medicinal food). J. Food Nutr Res. 2015;3(5): 330-336
  • 33. Kumaravel S, Alagusundaram K. Determination of mineral content in Indian spices by ICP-OES. Orient J Chem. 2014;30(2):631-636.
  • 34. Bae YJ, Kim MH, Lee JH, Choi MK. Analysis of six elements (Ca, Mg, Fe, Zn, Cu, and Mn) in several wild vegetables and evaluation of their intakes based on Korea National Health and Nutrition Examination Survey 2010–2011. Biol Trace Elem Res. 12015;64(1): 114-121.
  • 35. Conforti F, Tundis R, Marrelli M, Menichini F, Statti GA, De Cindio B, Houghton PJ. Protective effect of Pimpinella anisoides ethanolic extract and its constituents on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Med Food. 2010;13(1): 137-141.
  • 36. Shukla HS, Dubey P, Chaturvedi RV. Antiviral properties of essential oils of Foeniculum vulgare and Pimpinella anisum L. Agronomie. 1989;9(3): 277-279.
  • 37. Gülçın İ, Oktay M, Kıreçcı E, Küfrevıoǧlu Öİ. Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chem. 2003;83(3): 371-382.
  • 38. Tirapelli CR, de Andrade CR, Cassano AO, De Souza FA, Ambrosio SR, da Costa FB, de Oliveira AM. Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. J. Ethnopharmacol. 2007;110(1): 23-29.
  • 39. Al-Bayati FA. Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. J. Ethnopharmacol. 2008;116(3): 403-406.
  • 40. Mohammed MJ. Isolation and identification of anethole from Pimpinella anisum L. fruit oil. An antimicrobial study. J Pharma Res. 2009;2(5): 915-919.
  • 41. Kadan S, Rayan M, Rayan A. Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutra J. 2013;6(1): 1-5.
  • 42. Shobha RI, Rajeshwari CU, Andallu B. Anti-peroxidative and anti-diabetic activities of aniseeds (Pimpinella anisum L.) and identification of bioactive compounds. Am J Phtyomedicine Clin Ther. 2013;1(5): 516-527.
  • 43. AlSalhi MS, Devanesan S, Alfuraydi AA, Vishnubalaji R, Munusamy MA, Murugan K, Benelli G. Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. Int J Nanomedicine. 2016;11, 4439.
  • 44. Fitsiou E, Mitropoulou G, Spyridopoulou K, Tiptiri-Kourpeti A, Vamvakias M, Bardouki H, Pappa A. Phytochemical profile and evaluation of the biological activities of essential oils derived from the Greek aromatic plant species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita. Molecules. 2016;21(8): 1069.
  • 45. Hashem AS, Awadalla SS, Zayed GM, Maggi F, Benelli G. Pimpinella anisum essential oil nanoemulsions against Tribolium castaneum—insecticidal activity and mode of action. Environ Sci Pollut Res. 2018;25(19): 18802-18812.
  • 46. Amer AM, Aly UI. Antioxidant and antibacterial properties of anise (Pimpinella anisum L.). Egypt Pharm J. 2019;18(1): 68.
  • 47. Safaei-Ghomi J, Ebrahimabadi AH, Djafari-Bidgoli Z, Kashi JF, Batooli H. Bioactive properties of oil and methanol extracts of Pimpinella aurea DC. Am-Eurasian J Sustain Agric. 2009;3(2): 151-156.
  • 48. Ahn SM, Choi TH, Kwun IS, Sohn HY. Antifungal activity of methylene chloride fraction of Pimpinella brachycarpa against Aspergillus niger. Microbiol Biotechnol Lett. 2011;39(2):168-174.
  • 49. Kim SJ, Cho AR, Han J. Antioxidant and antimicrobial activities of leafy green vegetable extracts and their applications to meat product preservation. Food control. 2013;29(1): 112-120.
  • 50. Chang X, Kang W. Antioxidant and α-glucosidase inhibitory compounds from Pimpinella candolleana Wight et Arn. Med Chem Res. 2012;21(12): 4324-4329.
  • 51. Askari F, Sefidkon F, Teymourı M, Yousef NS. Chemical composition and antimicrobial activity of the essential oil of Pimpinella puberula (DC.) Boiss. J Agr Sci Tech. 2009c:11: 431-438.
  • 52. Ksouda G, Sellimi S, Merlier F, Falcimaigne-Cordin A, Thomasset B, Nasri M, Hajji M. Composition, antibacterial and antioxidant activities of Pimpinella saxifraga essential oil and application to cheese preservation as coating additive. Food Chem. 2019;288: 47-56.
  • 53. Sahibzada MUK, Ahmad W, El-Shehawi AM, Jafri I, Irfan S, Khusro A, Emran TB. Acetylcholinesterase inhibitory activity and iron-induced lipid peroxidation reducing potential of Pimpinella stewartii leaves in male wistar rats. J King Saud Univ Sci. 2022;34(4): 101993.
  • 54. Suleimen EM, Ibataev ZA, Iskakova ZB, Dudkin RV, Gorovoi PG, Aistova EV. Constituent composition and biological activity of essential oil from Pimpinella thellungiana. Chem Nat Compd. 2017;53(1): 169-172.
  • 55. Krupodorova T, Sevindik M. Antioxidant potential and some mineral contents of wild edible mushroom Ramaria stricta. AgroLife Sci J. 2020;9(1): 186-191.
  • 56. Bal C, Sevindik M, Akgul H, Selamoglu Z. Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma. 2019;37(1): 1-5.
  • 57. Selamoglu Z, Sevindik M, Bal C, Ozaltun B, Sen İ, Pasdaran A. Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P. Kumm. Biointerface Res Appl Chem. 2020;10(3):5500-5506
  • 58. Saridogan BGO, Islek C, Baba H, Akata I, Sevindik M. Antioxidant antimicrobial oxidant and elements contents of Xylaria polymorpha and X. hypoxylon (Xylariaceae). Fresenius Envir Bull. 2021;30(5): 5400-5404.
  • 59. Eraslan EC, Altuntas D, Baba H, Bal C, Akgül H, Akata I, Sevindik M. Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma. 2021;39(1): 24-28.
  • 60. Uysal İ, Mohammed FS, Şabik AE, Kına E, Sevindik M. Antioxidant and Oxidant status of medicinal plant Echium italicum collected from different regions. Turkish JAF Sci Tech. 2021;9(10):1902-1904.
  • 61. Baba H, Sevindik M, Dogan M, Akgül H. Antioxidant, antimicrobial activities and heavy metal contents of some Myxomycetes. Fresen Environ Bull. 2020;29(09):7840-7846.
  • 62. Mohammed FS, Uysal I, Sevindik M. A review on antiviral plants effective against different virus types. Prospects in Pharma Sci. 2023; 21(2): 1-21.
  • 63. Bal C, Akgul H, Sevindik M, Akata I, Yumrutas O. Determination of the anti-oxidative activities of six mushrooms. Fresenius Environ Bull. 2017; 26(10): 6246-6252.
  • 64. Islek C, Saridogan BGO, Sevindik M, Akata I. Biological activities and heavy metal contents of some Pholiota species. Fresen Environ Bull. 2021;30(6): 6109-6114.
  • 65. Akgul H, Korkmaz N, Dayangaç A, Sevindik M. Antioxidant potential of endemic Salvia absconditiflora. Turkish JAF Sci Tech. 2020;8(10): 2222-2224.
  • 66. Ashraf M, Ahmad R, Mahmood S, Bhatty MK. Studies on the essential oils of the Pakistani species of the family Umbelliferae. Part 45. Ferula assafoetida, Linn (Herra Hing) gum oil. Pak J Sci Ind Res. 1980;23(1-2): 68-69.
  • 67. Melkani AB, Javed MS, Melkani KB, Dev V, Beauchamp PS. Terpenoid composition of the essential oil from Pimpinella acuminata (Edgew.) CB Clarke. J Essent Oil Res. 2006;18(3): 312-314.
  • 68. Omidbaigi R, Hadjiakhoondi A, Saharkhiz M. Changes in content and chemical composition of Pimpinella anisum oil at various harvest time. J. Essent. Oil-Bear Pl. 2003;6(1): 46-50.
  • 69. Rodrigues VM, Rosa PT, Marques MO, Petenate AJ, Meireles MAA. Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. J Agric Food Chem. 2003;51(6): 1518-1523.
  • 70. Orav A, Raal A, Arak E. Essential oil composition of Pimpinella anisum L. fruits from various European countries. Nat Prod Res. 2008; 22(3):227-232.
  • 71. Samojlik I, Mijatović V, Petković S, Škrbić B, Božin B. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia. 2012;83(8): 1466-1473.
  • 72. Saibi, S., Belhadj, M., Benyoussef, EH. (2012). Essential oil composition of Pimpinella anisum from Algeria. Anal Chem Lett. 2012;2(6): 401-404.
  • 73. Ullah H, Mahmood A, Honermeier B. Essential oil and composition of anise (Pimpinella anisum L.) with varying seed rates and row spacing. Pak J Bot. 2014;46(5): 1859-1864.
  • 74. Khalid AK. Quality and quantity of Pimpinella anisum L. essential oil treated with macro and micronutrients under desert conditions. Int Food Res J. 2015;22(6): 2396.
  • 75. Askari F, Sefidkon F, Mozafarian V. Essential oil composition of Pimpinella aurea DC from Iran. Flavour Fragr J. 2005a;20(2): 115-117.
  • 76. Assadian F, Masoudi S, Nematollahi F, Rustaiyan A, Larijani K, Mazloomifar H. Volatile constituents of Xanthogalum purpurascens Ave-Lall., Eryngium caeruleum MB and Pimpinella aurea DC. Three Umbelliferae herbs growing in Iran. J Essent Oil Res. 2005;17(3): 243-245.
  • 77. Masoudi S, Rustaiyan A, Mazloomifar H. Composition of the Essential Oils of Pimpinella anisactis Rech. f. and Pimpinella saxifraga L. from Iran. J Essent Oil Res. 2009;21(2):146-148.
  • 78. Askari F, Sefidkon F. Volatile components of Pimpinella tragium Vill. from Iran. Iran J Pharm Sci. 2005b;2:117-120.


APA Mohammed, F. S. , Uysal, İ. , Sevindik, E. , Doğan, M. & Sevindik, M. (2023). Pimpinella species (Anise): Traditional use, Mineral, Nutrient and Chemical contents, Biological activities . International Journal of Traditional and Complementary Medicine Research , 4 (2) , 97-105 . DOI: 10.53811/ijtcmr.1306831
International Journal of Traditional and Complementary Medicine Research-Cover
  • ISSN: 2717-7491
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2020
  • Yayıncı: Düzce Üniversitesi
Sayıdaki Diğer Makaleler

Evaluation of University Students' Attitudes towards Traditional and Complementary Medicine Practices: A Study at a University in Türkiye

Emine SARMAN, Şevval KOCABIYIK, Merve Betül KARACİF, Zahide Nur KARAKOYUNCU, Mustafa Samed UÇAR, Ahmet SAYAR, Çağrı YILMAZ

Acupuncture for Obesity

Duygu İlke YILDIRIM, Mehmet Ali ERYILMAZ

Pimpinella species (Anise): Traditional use, Mineral, Nutrient and Chemical contents, Biological activities

Falah Saleh MOHAMMED, İmran UYSAL, Emre SEVİNDİK, Muhittin DOĞAN, Mustafa SEVİNDİK

The Medicinal Plants Traditionally Used Against Cardiovascular Diseases In Türkiye

Meltem GÜLEÇ, Zeynep Büşra ERARSLAN, Şükran KÜLTÜR

Biological Activity of Natural Formulation with Propolis, Lavender and Thyme Oil on Candida Species


Fever and the Ageing Immune system, A Review


Preparation of Centella asiatica (L). and Hypericum perforatum (St. John's Wort) Plant Extracts and Development of Anti-Aging Herbal Cream Formulations

Elif AYDINLI, Bayram DEMİR, Haydar GÖKSU

Combination Therapy of Major Autohemotherapy and Ozonated Bagging in a Case Diagnosed with Buerger's Disease (Thromboangiitis Obliterans)

Safa ÜNAL, Abdulkadir KAYA, Alper AYASLI, Bekir TUNCA

The Effects of Sacral Massage and Music Therapy Applied to Primaparous Women in Labor on Labor Pain, Postpartum Comfort, and Posttraumatic Growth: A Randomized Controlled Trial