This study aims at investigating the effects of Islamic Science,Technology And Engineering course towards the changes of attitude, moral and behaviour of students Architecture of a polytechnic in Malaysia.  50 students of Architecture Diploma programmes who had taken Islamic science,technology and engineering course in semester July 2016 were involved in this study.  Data were collected using a set of questionnaires regarding the students’ perceptions towards Islamic science,technology and engineering course and were analysed using percentage, frequency, t-test and correlation test.  The findings show that the overall mean for the increment of the students’ understanding and awareness of Islamic science,technology and engineering is 4.41, their perceptions towards Islamic science,technology and engineering course is 4.29, the students’ perceptions towards Islamic science,technology and engineering lecturers is 4.55, their perceptions towards daily activities is 4.74 whereby the students’ perceptions towards the teaching of Islamic science,technology and engineering course is 4.12.  The results of the t-test showed that independent variables had only a little influence on the dependant variables based on the significant level which is 0.05.  Apart from that, based on the overall mean and percentages on the changes of the students’ attitude, this study found that the Islamic science,technology and engineering course had given positive effects on the students of the polytechnic.