This study was carried out to investigate the performance of no-tilled, drip irrigated, second crop safflower under South East Anatolia (Mardin) conditions. For this aim, a three replicated trial was established in year 2014 with Dincer and Remzibey-05 cultivars. Biomass production was so low and plant height average was 50 cm. under these conditions. The average seed yield of Dincer cv. was 503 kg/ha and Remzibey-05 cv. was 488 kg/ha. Plant height of Dincer was 52.9 cm and Remzibey-05 was 47.7 cm. According to the results, it was found that safflower is a high temperature sensitive plant. With the tested varieties, no-tilled, drip irrigated, second crop safflower it is not rantabl in South East Anatolia conditions and can not compete with maize. Breeding effords are needed to improve the tolerance of safflower to high temperatures to adopt this crop to this conditions. This study revealed the potential of safflower to conduct speed breeding activities in that crop with three to four breeding cycles in one year.