Bedriye Seda KURŞUN AKTAR, Ayşe ŞAHİN YAĞLIOĞLU, Emine Elçin ORUÇ-EMRE

8683

The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma

The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma

The anticancer activities 3-(substituted phenyl)-1-[4-(morpholine-4-yl)phenyl]prop-2-en-1-one derivatives were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed by the BrdU ELISA method. 5-Fluorouracil (5-FU) was used as standard compound. Compound 1-7 (except Compound 3) were determined to have higher anticancer activity than 5-FU aganist PC3 cancer cells. IC50 values of the Compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM; 4.40±0.03 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.

Keywords:

HT29, PC3, Chalcone 5-Fluorouracil, Fluor atom, anticancer activity,

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Reference1: Prof. Dr. İbrahim Demirtaş (ibdemirtas@gmail.com) Reference2: Prof. Dr. Nurettin Yaylı (nurettin yayli@ktu.edu.tr )

International Journal of Chemistry and Technology-Cover

Yayın Aralığı: Yılda 2 Sayı
Başlangıç: 2017
Yayıncı: İbrahim DEMİRTAŞ

Arşiv

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