Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

___

  • Ozdemir, F.; Kayaaltı, Z.; Dilek, K. A. Marmara Pharm. J. 2015, 19(3), 246-251.
  • Zemheri, F.; Cevdet, U. Marmara Üniv. Fen Bilim. Derg. 2018, 30(1), 71-76.
  • Urriola-Muñoz, P.; Li, X.; Maretzky, T.; McIlwain, D.R.; Mak, T.W.; Reyes, J.G.; Blobel, C.P.; Moreno, D. J. Cell. Physiol. 2018, 233(3), 2247-2256.
  • Abou Khalil, N. S.; Abd‐Elkareem, M.; Sayed, A. H. Aquac. Nutr. 2017, 23(6), 1467-1474.
  • Dobrzyńska, M. M. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 772, 14-19.
  • Vazquez-Duhalt, R.; Marquez-Rocha, F.; Ponce, E.; Licea, A.F.; Vaiana, M.T. Appl. Ecol. Environ. Res. 2005, 4:1-25.
  • Wu, F.; Lin, L.; Qiu, J.W.; Chen, H.; Weng, S.; Luan, T. Aquat. Toxicol. 2014, 155, 43-51.
  • Shirdel, I.; Mohammad, R.K. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 183-184, 28-35.
  • Fenech, M.; Chang, W. P.; Kirsch-Volders, M.; Holland, N.; Bonassi, S.; Zeiger, E. Mut. Res. 2003, 534, 65-75.
  • Baršienė, J.; Dedonytė, V.; Rybakovas, A.; Andreikėnaitė, L.; Andersen, O. K. Aquat. Toxicol. 2006, 78, 99-104.
  • Lambert, I.B.; Singer, T.M.; Boucher, S.E.; Douglas, G.R. Mutat. Res. 2005, 590, 1-280.
  • Mavourni, K.H.; Blakey, D.H.; Cimino, M.C.; Salamone, M.F.; Heddle, J.A. Mutat. Res. 1990, 239, 29-80.
  • Celik, A.; Mazmanci, B.; Camlica, Y.; Askin, A.; Comelekoglu, U. Mutat. Res. 2003, 539, 91-97.
  • Bara, M.; Bitgen, N.; Kalkan, K.T.; Goktepe, O.; Varol, S.; Yay, A.H. Dicle Tip Derg. 2022, 49(1), 36-44.
  • Aksu, P.; Doğan, A.; Gül, S.; Kanıcı, A. Kafkas Univ. Vet. Fak. Derg. 2013, 19(6), 955-961.
  • Mekkawy, I. A.; Mahmoud, U. M.; Sayed, A.H. Tissue and Cell. 2011, 43, 223-229.
  • Sharma, M.; Chadha, P. Drug Chem. Toxicol. 2017, 40(3), 320-325.
International Journal of Chemistry and Technology-Cover
  • Yayın Aralığı: Yılda 2 Sayı
  • Başlangıç: 2017
  • Yayıncı: İbrahim DEMİRTAŞ
Sayıdaki Diğer Makaleler

Antioxidant and oxidant status, DPPH activity, total phenolic and flavonoid contents of mountain tea (Sideritis libanotica subsp. kurdica (Bornm.) Hub.-Mor)

İmran UYSAL, Falah Saleh MOHAMMED, Oğuzhan KOÇER, Muhittin DOĞAN, Mustafa SEVİNDİK

Doğu Akdeniz koşullarında ikinci ürün olarak yetiştirilen bazı hibrit mısır genotiplerinde tane ve yem verimi ile yem kalite özelliklerinin değerlendirilmesi

İbrahim ERTEKİN, Ömer KONUŞKAN, İbrahim ATIŞ

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Nazmiye BİTGEN, Özge GÖKTEPE, Münevver BARAN, Eren Kaan İPEK, Arzu YAY

Heat energy transport characteristics of microchannel reactors for hydrogen production by steam-methanol reforming on copper-based catalysts

Junjie CHEN

Antifungal activity and optimization procedure of microwave-synthesized silver nanoparticles using linden (Tilia rubra subsp. caucasica) flower extract

Uğur YİĞİT, Muharrem TÜRKKAN

Chemical extraction of Biodiesel and Parametric analysis of DI-Diesel Engine using Algae esterified Oil-Gasoline Blends

Rajesh KUMAR, Panduranga MURTHY G

Isotherm and kinetic modeling of the adsorption of methylene blue, a cationic dye, on pumice

Kübra GÜNEŞ

Fruit fly (Diptera: Tephritidae) fauna in Tokat province (Türkiye)

Tuğçe İŞİNİ, Murat KÜTÜK, Mehmet YARAN

Tribological performance of polyamide 6/wax blend for rolling bearing, bushing and gear applications

Hüseyin ÜNAL, Salih Hakan YETGİN, Sinan KÖSE

Production and characterization of polyamide-6 (PA6) and cellulose acetate (CA) based nanofiber membranes by electrospinning method

Dr. Abdullah GÜL, İsmail TİYEK