KARACİĞER BİYOPSİ İLE NONALKOLİK YAĞLI KARACİĞER HASTALIĞI TANISI ALAN 220 HASTANIN RETROSPEKTİF DEĞERLENDİRİLMESİ

Non alkolik yağlı karaciğer hastalğı (NAYKH) alkol tüketimi olmadan karaciğer yağlanması olarak tanımlanır. NAYKH, dünyada en sık görülen kronik karaciğer hastalığı olarak bilinir. NAYKH, siroz ve hepatoselüler kanser gibi ciddi hastalıklara sebep olabilmektedir. Bu çalışmada karaciğer biyopsisi ile NAYKH tanısı alan 220 hastayı retrospektif olarak değerlendirmeyi amaçladık. Araştırmaya 2010-2019 yılları arasında Demiroğlu Bilim Üniversitesi Tıp Fakültesi gastroenteroloji polikliniğinde takip edilen karaciğer biyopsi ile NAYKH tanısı alan toplam 220 hasta alındı. Olguların demografik (yaş, cinsiyet, boy, kilo, beden kitle indeksi (BMI), laboratuvar (biyokimyasal parametreler) ve biyopsi sonuçları hastane bilgi sisteminden ve dosyalarından retrospektif olarak toplandı. Hastaların yaş ortalaması 34.14 ± 6.72 ve % 60’ı erkek, % 40’ı kadındı. Erkek ve kadın hastalarda karaciğer yağlanma yüzdesi ortalaması benzerdi (p: 0.41). Hastaların BMI ortalaması: 27.32 ± 3.02, ortalama karaciğer steatoz yüzdesi % 12.1 ± 8.68 ve ortalama Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) değeri 2.64 saptandı. Yağlanma derecesi ile BMI, aspartat aminotransferaz, alanin aminotransferaz, alkalen fosfataz, gamaglutamil transferaz, total kolesterol, trigliserit , kreatinin ve HOMA-IR arasında pozitif korelasyon saptanırken yaş, üre ve total biluribin ile herhangi bir korelasyon belirlenmedi. Çalışmamızda genç ve orta yaş grubu ile obez olmayan kişilerde de NAYKH görülebileceği, BMI ve insülin direncinin bu hasta grubunda da NAYKH ile ilişkili olabileceği gözlendi. Ayrıca, karaciğer enzimleri normal aralıkta olsa bile NAYKH ile ilişkili olabilecekleri görülmüştür. Yeni ve daha geniş kapsamlı çalışmalarla, bu konuda daha güvenilir veriler elde edilebileceği düşünülmektedir.

Anahtar Kelimeler:

Karaciğer yağlanması, NAFLD, hepatosteatoz

RETROSPECTIVE EVALUATION OF 220 PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE DIAGNOSED BY LIVER BIOPSY

Non-alcoholic fatty liver disease (NAFLD) defined as fatty accumulation in liver without alcohol consumption. NAFLD is known as the most common chronic liver disease worldwide. NAFLD can cause serious diseases such as cirrhosis and hepatocellular cancer (HCC). We aimed to evaluate retrospectively 220 liver biopsy proven patients with NAFLD in this study. A total of 220 patients diagnosed with NAFLD by liver biopsy followed in the gastroenterology outpatient clinic of Demiroğlu Bilim University Faculty of Medicine between 2010-2019 were included in the study. Demographic data (age, gender, height, weight and body mass index), biochemical laboratory parameters and biopsy results were scanned and recorded retrospectively from hospital information system and files of patients. The mean age of the patients was 34.14 ± 6.72 and 60% of the patients were male and 40% were female. Mean liver steatosis percentage was similar in male and female patients (p: 0.41). The mean BMI of the patients was 27.32 ± 3.02, the mean liver steatosis percentage was 12.1 ± 8.68% and the mean Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) value was 2.64. There was a positive correlation between liver steatosis and BMI, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamaglutamyl transferase, total cholesterol, triglyceride, creatinine and HOMA-IR, but no correlation was found between liver steatosis and age, urea and bilirubin. In our study, it was observed that NAFLD can be seen in young and middle-aged, non-obese individuals, and BMI and insulin resistance may be associated with NAFLD in this patient group. In addition, liver enzymes were found to be associated with NAFLD even if they were in the normal range. More reliable data can be obtained with new and more extensive studies.

Keywords:

Liver steatosis, NAFLD, hepatosteatosis,

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