D VİTAMİNİ EKSİKLİĞİ NEDENİYLE TEDAVİ ALAN POLİKİSTİK OVER SENDROMLU HASTALARIN KLİNİK, METABOLİK VE ULTRASONOGRAFİK PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Amaç: Bu çalışmada, D vitamini eksikliği nedeniyle tedavi alan polikistik over sendromlu hastaların klinik, metabolik, ultrasonografik parametrelerinin değerlendirilmesi amaçlanmıştır. Materyal-Metod: Dokuz Eylül Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Üreme Endokrinolojisi ve İnfertilite Bilim Dalı Polikliniği’ne 01/12/2013-01/12/2014 tarihleri arasında başvuran polikistik over sendromu tanısı konulan toplam 95 hasta çalışmaya alınmıştır. D vitamini eksikliği nedeniyle tedavi alan polikistik over sendromlu hastaların 3 aylık tedavi sonrasındaki klinik, metabolik, ultrasonografik parametreleri retrospektif olarak değerlendirilmiştir. Bulgular: Vitamin D3 kullanımı sonrasında 0.ay ve 3.ay arasında kilo,bel çevresi,kalça çevresi,bel/kalça oranı, LH, FSH, estradiol, total testosteron, PRL, TSH, OGTT düzeyi, insülin, 17-OH progesteron, HDL, LDL, trigliserit, total kolesterol, açlık kan şekeri düzeyi, ortalama arteriyal kan basıncı, androstenedion, SHBG, VKİ, HOMA-IR, total over volümü değerleri arasında anlamlı farklılık izlenmedi. Ferriman gallwey skoru, adet düzeni, 25-OH D vitamini düzeyi, DHEAS düzeyi, free testosteron, LH/FSH oranı, total antral folikül sayısı, free androjen indeks düzeyinde istatistiksel olarak anlamlı azalma saptandı. 25-OH D vitamin düzeyi artışı ile LH/FSH oranı düzeyi, total antral folikül sayısı, serbest androjen indeksi düzeyi, DHEAS düzeyi azalması korelasyonu, pearson korelasyon analizi ile değerlendirildi ve istatistiksel olarak anlamlı farklılık saptanmadı[(p

Anahtar Kelimeler:

Polikistik over sendromu, 25-OH D Vitamini, tedavi

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