Bilge Şen, Özlem Ekiz, Emine Rifaioğlu, Tuğba Şen, Asena Doğramacı

ALOPESİ AREATADA TOPİKAL PSORALEN VE ULTRAVİOLE A FOTOKEMOTERAPİSİNİN ETKİNLİĞİNİN DEĞERLENDİRİLMESİ

Amaç: Alopesi areata (AA), saç folliküllerinietkileyen kronik inflamatuar bir deri hastalığıdır.Bu çalışmada AA’lı hastalarda topikal psoralen veultraviyole A (PUVA) tedavisinin etkinliği vegüvenilirliğinin değerlendirilmesi amaçlanmıştır.Gereç ve yöntemler: Ocak 2009 ve Aralık 2012tarihleri arasında kliniğimiz fototerapi ünitesindeAA tanısı ile topikal PUVA tedavisi gören hastalaraait veriler retrospektif olarak incelendi. Klinikyanıt, yeni kıl çıkışı %75 ve üzerinde ise “iyiyanıt”, %51-74 ise “orta yanıt”, %50 ve altında ise“yanıt yok” olarak tanımlandı.Bulgular: Çalışmaya yaşları 3 ile 59 arasındadeğişen 32 hasta dahil edildi. On dördü kadın(%43.8), 18’i erkek (%56.3) olan hastaların 9tanesinin yaşları 18 altındaydı. Hastalık süreleri 6ay ile 20 yıl arasında değişmekteydi. On dörthastada (%43.8) iyi yanıt, 9 hastada (%28.1) ortayanıt saptandı ancak 9 hastada (%28.1) tedaviyeyanıt elde edilemedi. Hastaların total seans sayısıortalaması 70.1 ± 32.5 ve total kümülatif dozortalaması 450.1 ± 284.8 J/cm2 olarak belirlendi.Fototerapiye bağlı akut yan etkiler sadece üçhastada izlendi.Sonuç: Topikal PUVA fotokemoterapisi AA’daetkili ve iyi tolere edilen bir tedavi yöntemidir.

Anahtar Kelimeler:

Alopesi areata, fototerapi, fotokemoterapi

Evaluation of the efficacy of topical psoralen and ultraviolet A photochemotherapy in alopecia areata

Aim: Alopecia areata (AA) is a chronic inflammatory skin disease that affects the hair follicles. In this study, we aimed to evaluate the efficacy and safety of topical psoralen and ultraviolet A (PUVA) treatment in patients with AA. Material and methods: The data of the patients with AA who were treated in phototherapy unit of our clinic between January 2009 and December 2012 were analyzed retrospectively. Clinical response was named as "good response”, "moderate response” or “no response” when the new hair output is 75% and higher, 51-74%, 50% and below, respectively. Results: Thirty two patients whose ages between 3 and 59 were included to the study. Fourteen (43.8%) were female, 18 (56.3%) male patients, 9 of them were under 18 years of age. Duration of disease of the patients ranged from 6 months to 20 years. Fourteen patients had good response (43.8%), 9 patients (28.1%) had moderate response but the response to treatment could not be obtained in 9 patients (28.1%). The mean total number of sessions was 70.1 ± 32.5 and the mean total cumulative dose was 450.1 ± 284.8 J/cm2. Acute side effects of phototherapy were observed in three patients. Conclusion: Topical psoralen and ultraviolet A (PUVA) photochemotherapy is an effective and safe treatment modality in AA

Keywords:

Alopecia areata, phototherapy, photochemotherapy,

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