Mehmet YILMAZER, Mine PEKTAŞ KANAT, Dağıstan Tolga ARIÖZ, Yunus YILDIZ, Akif ACAY, Gülen Gül KÖKEN, Elif TELCİLER, Bekir Serdar ÜNLÜ

The Role of mean platelet volume in preeclampsia

Amaç : Preeklampsi gebeliğin 20. haftasından sonra hipertansiyon ve proteinüri gelişimi ile karakterize gebeliğe özgü, multisistemik birhastalıktır. Bu çalışmada, ortalama trombosit hacminin hastalığın ciddiyetine ve hastalığın erken ya da geç ortaya çıkmasına göre ilişkisiniortaya koymayı amaçladık.Gereç ve Yöntemler: Bu retrospektif çalışmaya, preeklampsi tanısı almış 46 hasta ve kontrol grubu olarak 49 sağlıklı gebe kadın dahiledildi. Preeklampsi grubundaki hastalar erken veya geç ve hafif veya ağır hastalık olarak gruplara ayrıldı. Gruplar yaş, hemoglobin,hematokrit, trombosit sayısı, ortalama trombosit hacmi, trombosit dağılım aralığı ve gebelik haftaları açısından karşılaştırıldı. İki gruparasındaki parametrelerin karşılaştırılması için bağımsız örneklem t-testi kullanıldı.Bulgular: Gruplar arası yaş ortalaması benzerdi (preeklampsi=30±6.9 ve kontrol=28.4±5.3, p=0.125). Her iki grup arasında gebelik haftalarıyönünden anlamlı fark yoktu (p=0.2). Preeklampsi grubunda ortalama trombosit sayısı (x103 /μL) 207±83 ve kontrol grubunda 205±51bulundu ve gruplar arasında anlamlı fark yoktu (P=0.78). Preeklampsi grubunda ortalama trombosit hacmi kontrol grubundan anlamlı olarakdaha yüksek bulundu (sırasıyla; 10.8±1.3 ve 9.8±1,3) (P=0.03). Ortalama trombosit dağılım aralığı preeklampsi ve kontrol grubunda sırasıyla,15.3±2.8 ve 14.8±2.5 bulundu ve iki grup arasında fark yoktu (P=0.34).Sonuç : Ortalama trombosit hacmi, preeklampsi grubunda kontrol grubundan daha yüksek bulundu. Ancak, preeklampsinin erken veya geçolmasında ve preeklampsinin ağırlığı açısından ortalama trombosit hacminde bir farklılık bulunmadı.

Ortalama platelet hacminin preeklampside rolü

Objective : Preeclampsia is a pregnancy-specific, multisystem disorder characterized by the development of hypertension and proteinuria20 weeks after gestation. We investigated the role of mean platelet volume in preeclampsia according to the emergence of the disease, asbeing early or late, and its severity.Material and Methods: Forty-six preeclamptic women and 49 healthy pregnant women as the control group were included in thisretrospective study. Preeclamptic patients were divided into groups. Age, hemoglobin count, hematocrit, platelet count, mean plateletvolume, platelet distribution width, and pregnancy weeks of the groups were compared with each other. Results: The mean age of the groups was similar (preeclampsia=30±6.9 and control=28.4±5.3, p=0.125). There was no statisticallysignificant difference between the two groups in terms of gestational weeks (P=0.2). The mean platelet count (x103 /μL) was 207±83 in thepreeclamptic group and 205±51 in the control group and there was no statistically significant difference between the groups (P=0.78). Itwas found that the mean platelet volume was notably higher in the preeclamptic group (10.8±1.3 and 9.8±1.3, respectively) (P=0.03). Theplatelet distribution width values of the preeclamptic group and the control group were 15.3±2.8 and 14.8±2.5, respectively, and there wasno statistically significant difference between the groups (P=0.34).Conclusion : Mean platelet volume was higher in the preeclamptic group than the control group. However, as far as mean platelet volumeis concerned, there were no differences between the emergence of preeclampsia as early or late, or the severity of preeclampsia.

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