POLİKİSTİK OVER SENDROMU FENOTİPLERİ VE METABOLİK DİSFONKSİYON İLİŞKİSİ

Polikistik over sendromunun (PKOS) hangi fenotipinin daha yüksek metabolik riske sahip olduğu tartışmalıdır. Bu çalışma üçüncü basamak bir hastanede metabolik sendrom (MetS) insidansını ve farklı fenotipler için metabolik riski karşılaştırmayı amaçladı. Endokrinoloji ve Metabolizma Hastalıkları Kliniği'ne klinik hiperandrojenizm ve/veya düzensiz menstrüasyon şikayetleri ile başvuran ve Rotterdam kriterlerine göre tanı konulan PKOS olguları retrospektif olarak incelendi. Hastalar Rotterdam kriterlerine göre dört fenotipe ayrıldı ve gruplar MetS prevalansı ve metabolik risk açısından karşılaştırıldı. Toplam 100 hasta çalışmaya alındı. MetS prevalansı fenotip A'da %30.3, fenotip B'de %24.1, fenotip C'de %15.4 ve fenotip D'de %36 idi. Fenotip A'da obezite (BKİ> 30 kg/m2) ve HOMA-IR> 2.5 insidansı daha yüksek olmasına rağmen, gruplar arasındaki fark anlamlı değildi. Tüm hastalar obez ve obez olmayan hastalar olarak gruplandırıldığında, metabolik sendrom varlığı obez hastalarda anlamlı oranda fazla görüldü (p <0.001) ve LH/FSH oranı obez hastalarda anlamlı olarak yüksek bulundu (p=0.011). Sonuç olarak metabolik sendrom varlığı obez hastalarda ve LH/FSH oranı obezite varlığında anlamlı olarak yüksekti ancak dört fenotip arasında fark görülmedi.

Anahtar Kelimeler:

Fenotip, Metabolik sendrom, Polikistik over sendromu, Risk faktörü

The Relationship Between Polycystic Ovary Syndrome Phenotypes and Metabolic Dysfunction

Which phenotype of polycystic ovary syndrome (PCOS) has a greater metabolic risk is controversial. This study aimed to compare the incidence of metabolic syndrome (MetS) and metabolic risk for different phenotypes in a tertiary hospital. Women who applied to the Endocrinology and Metabolic Diseases Clinic with complaints of clinical hyperandrogenism and/or irregular menstruation and were diagnosed as PCOS according to the Rotterdam criteria were retrospectively analyzed. Patients were classified into four phenotypes according to the Rotterdam criteria, and the groups were compared in terms of MetS prevalence and metabolic risk. A total of one hundred patients were included in the study. Prevalence of MetS was 30.3% in phenotype A, 24.1% in phenotype B, 15.4% in phenotype C, and 36% in phenotype D. Although the incidence of obesity (BMI> 30 kg/m2) and HOMA-IR> 2.5 were higher in phenotype A, differences were not statistically significant. In the overall collective the presence of metabolic syndrome was significantly higher in obese patients (p <0.001), and LH/FSH ratio was found to be significantly higher in the presence of obesity (p=0.011). In summary, the presence of metabolic syndrome was significantly higher in obese patients and the LH/FSH ratio was significantly higher in the presence of obesity, but no difference was found between the four phenotypes.

Keywords:

Metabolic syndrome, Phenotype, Polycystic ovary syndrome, Risk factor,

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