Semantik Analiz Yönteminin Kur’ân’a Uygulanması

Periodontitis ve obezite iki kronik enflamatuar hastalıktır. Obezite ve periodontitis sistemik enflamasyonla ilgili olduklarından bu iki hastalığın ortak patofizyolojiye sahip olduğu söylenebilir. TNF-alfa ve IL-6 obezite ve periodontitisin patofizyolojisinde yer alan sitokinlerdir. Bu sitokinlerin seviyeleri obezite ve periodontitis ile birlikte artar. Resistin immun hücreler tarafından üretilir ve bu yüzden de enflamatuar sürecin aktivasyonunda yer alır. Resistinin pro-enflamatuar özellikleri TNF-alfa ve IL-6 salınımı ve adiponektinin anti-enflamatuar etkilerinin bozulmasıdır. Periodontitiste serumda resistin seviyesi artmaktadır. Aynı zamanda adipoz dokular da adiponektin gibi bazı anti-enflamatuar faktörleri salgılamaktadır. Obez bireylerde normal ağırlıktaki bireylere göre plazmada azalmış adiponektin seviyeleri görülmektedir. Ayrıca bilimsel kanıtlar periodontitisli bireylerde serum adiponektin seviyesinin ve fonksiyonunun azaldığını göstermektedir. Sonuç olarak, periodontitis ve obezite çeşitli sitokinler, proteinler, ve vitaminler aracılığıyla birbirleri ile ilişkili iki hastalıktır.

Anahtar Kelimeler:

Periodontit, obezite, TNF-alfa, IL-6, rezistin

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