Serap GÜNGÖR KOÇ, Redar Wasurahman AHMED

Kemik İmplant Uygulamalarında Kullanılmak Üzere Çeşitli İyonlar Eklenmiş Nano-Trikalsiyum Fosfatların Üretimi ve Karakterizasyonu

Diş ve ortopedik protezlerin üretiminde kalsiyum fosfat (CaP) bazlı biyoseramikler sıklıkla kullanılmaktadır. Özellikle, kemiğin kimyasal ve yapısal benzerliklerinden dolayı tercih edilmektedirler. Stronsiyum (Sr2+), florür (F−) ve klorür (Cl-) iyonlarının kemik ve dişlerin metabolizmasında ve yapısında önemli rol oynadığı bilinmektedir. Bu çalışmanın amacı stronsiyum, klorür ve florür iyonları ile katkılandırılmış tri-kalsiyum fosfatların üretilmesidir. Saf ve katkılandırılmış tri-kalsiyum fosfatlar çöktürme yöntemi kullanılarak sentezlenmiştir. Katkısız ve katkılandırılmış numuneler 1 saat süresince 1100°C ‘de sinterlenmiştir. Stronsiyum (Sr+2) ve klorürün (Cl-) ilavesi ile numunelerin yoğunluğunu azalırken, florür (F-) miktarının artmasıyla numunelerin yoğunluklarında artış gözlemlenmiştir. XRD sonuçları α-TCP ve β-TCP fazlarının varlığını ortaya koymuştur. SEM görüntüleri sinterleme sıcaklığının ve katkılandırılan iyon miktarlarının numuneler üzerindeki tane büyüklüklerine anlamlı bir etkiye sahip olduğunu doğrulamaktadır.

Anahtar Kelimeler:

Biyomalzemeler, klor, flor, çöktürme yöntemi, stronsiyum, tri-kalsiyum fosfat

Fabrication and Characterization of Nano-TCP Doped with Various Ions for Bone Implant Applications

Calcium phosphate (CaP) based bioceramics are frequently used in dental and orthopedic field as bone grafts due to their chemical and structural similarities to the human hard tissues. Strontium (Sr2+), fluoride (F−) and chloride (Cl-) ions are known to play important role in bone and tooth microstructure. The aim of this study was to combine tri-calcium phosphates doped with strontium, chloride and fluoride ions. A precipitation procedure was applied for synthesizing pure and doped tri-calcium phosphates. The undoped and doped samples were sintered at 1100°C for 1 h. Incorporation of the strontium (Sr+2) and chloride (Cl-) ions decreased the density of the samples while, the fluoride (F-) co-doped densities increased with respect to pure TCP. The XRD results revealed the existence of the α-TCP and β-TCP phases. SEM results confirmed the sintering temperature and amount of dopants had prominent effect on the grain sizes of the samples.

Keywords:

Biomaterials, chloride, fluoride, precipitation method, strontium, tri-calcium phosphate,

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