DİYABETİK SIÇANLARDA IL-6 VE TNF-α SEVİYELERİ: KUERSETİNİN ETKİSİ
Flavonoidler sağlık açısından faydalarına istinaden geleneksel tıpta yaygın kullanılan fenolik bileşiklerdir. Flavonoidlerin alt ailesi olan flavonoller içerisinde kuersetin, yüksek biyolojik aktivitesi ile dikkat çekmektedir. Flavonoidlerin diyabetes mellitus tedavisinde destekleyici ajanlar olarak kullanılması sıkça tartışılmaktadır. Diyabet fizyopatogenezinde söz edilen inflamasyon, destekleyici tedavi açısından bir hedef olarak görülebilir. Buradan hareketle mevcut çalışmamızda diyabetik sıçanlarda kuersetinin plazma inflamatuar sitokinlerinden olan interlökin-6 (IL-6) ve tümör nekroz faktör-α (TNF-α) seviyelerine etkisinin araştırılması amaçlanmıştır. Diyabetik ve non-diyabetik iki ana grup içerisinde kontrol ve tedavi (50 mg/kg ve 100 mg/kg kuersetin) olmak üzere toplam altı alt grup oluşturulmuştur. Diyabetik hayvanlarda plazma IL-6 ve TNF-α seviyelerinde önemli düzeyde artış izlenmiştir (sırasıyla p=0,01 ve p=0,01). Her iki kuersetin dozu diyabetik hayvanlarda yükselen plazma IL-6 ve TNF-α seviyelerinin non-diyabetik hayvanlar düzeyine düşürülmesini sağlamıştır (sırasıyla p=0,01 ve p=0,01). İnflamatuar sitokin seviyeleri açısından diyabetik olmayan sıçanlarda kuersetin enjeksiyonu yapılan ve yapılmayan hayvanlar arasında farka rastlanmamıştır (p=0,99). Bu bulgular kuersetinin diyabetik sıçanlarda immünosupresandan ziyade immünomodülatör olarak davrandığını düşündürmektedir. Anahtar Kelimeler:
Anahtar Kelimeler:
Kuersetin, diyabetes mellitus, inflamasyon, interlökin-6, tümör nekroz faktör-α
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Flavonoids are widely used phenolic compounds in traditional medicine due to their health-beneficial features. Quercetin is a remarkable member of flavonols, which is a sub-family of flavonoids, with its broad biological activity. Using flavonoids as adjuvant agents in the treatment of diabetes mellitus is frequently being debated. Inflammation, which is mentioned in the pathophysiology of diabetes, may be seen as a target for the adjuvant therapy. Thereby, in the present study, we aimed to investigate the effects of quercetin on the plasma inflammatory cytokines, namely interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in diabetic rats. Total six groups were assigned as controls and treatments (50 mg/kg and 100 mg/kg quercetin) in diabetic and non-diabetic main groups. We found that diabetes resulted in a significant increase of plasma IL-6 and TNF-α levels (respectively p=0,01 and p=0,01). Both doses of quercetin reduced plasma IL-6 and TNF-α to the levels that in non-diabetic animals (respectively p=0,01 and p=0,01). In terms of inflammatory cytokine levels, there was no significance between non-diabetic quercetin injected and control animals (p=0,99). Therefore, we assumed that quercetin acts as an immunomodulator rather than an immunosuppressant in diabetic rats
Keywords:
Quercetin, diabetes mellitus, inflammation, interleukin-6, tumor necrosis factor-α,
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- Başlangıç: 2013
- Yayıncı: Tüm Bilim İnsanları ve Akademisyenler Derneği
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