Varyant B.1.1.7 Pozitif ve Negatif SARS-CoV-2 Enfeksiyonunda Akut Böbrek Yetmezliği ve Mortalitenin Karşılaştırılması

Amaç:. Bu çalışmada varyant B.1.1.7 pozitif ve negatif SARS-CoV-2 enfeksiyonu olan hastalarda akut böbrek hasarı gelişimi ve mortalite oranlarının karşılaştırılması amaçlanmıştır. Materyal ve Metod: Çalışmaya varyant B.1.1.7 negatif 92 (grup I) ve 57 varyant B.1.1.7 pozitif 57 (grup II) SARS-CoV-2 hastası dahil edildi. Her hastanın demografik verileri, komorbiditeleri, yoğun bakım yatış gün sayıları, invaziv mekanik ventilatör ihtiyacı, mekanik ventilatör gün sayısı, akut böbrek yetmezliği gelişip gelişmediği, gelişti ise kaçıncı günde akut böbrek yetmezliği geliştiği ve tedavinin sonlanım şekilleri kaydedildi. Bulgular: Grup II hastalara 17/57 (29.8%) grup I hastalara 31/92 (33.7%) göre daha fazla oranda akut böbrek hasarı gelişti (p=0.04). Grup I’de 46/92 (50 %) grup II’de 38/57 (66.7%) hasta hasta invaziv mekanik ventilasyon desteğine alındı (p <0.05). Akut böbrek hasarı gelişmeyen hastaların mortalite oranı grup II’de 22/40 (55%) grup I’e 19/61 (31.2%) göre daha yüksekti (p<0.05). Sonuç: Varyant B.1.1.7 enfeksiyonu olan hastalarda akut böbrek hasarı gelişiminin diğer grup hastalara göre daha az olduğu saptanmıştır. Varyant B.1.1.7 enfeksiyonundaki mortalite artışının akut böbrek hasarı gelişiminden bağımsız olarak gerçekleştiğini düşündürmektedir.

Anahtar Kelimeler:

COVID-19, varyant B.1.1.7, akut böbrek hasarı, mortalite

Comparison of Acute Kidney Injury and Mortality in Variant B.1.1.7 Positive and Negative SARS-CoV-2 Infection

Background:This study aimed to compare the acute kidney injury AKI) development and mortality rates in patients with variant B.1.1.7 positive and negative SARS-CoV-2 infection. Material and Methods: 92 variant B.1.1.7 negative (group I) and 57 variant B.1.1.7 positive (group II) SARS-CoV-2 patients were included in the study. Demographic data, comorbidities, the number of intensive care unit hospitalization days, the need for an invasive mechanical ventilator, number of mechanical ventilator days, whether acute renal failure developed, the day of acute renal failure development, and treatment outcome were recorded for each patient. Results: Group II patients (17/57 -29.8%) developed acute kidney injury at a higher rate than group I patients (31/92 -33.7%) (p=0.04).. 46/92 (50%) patients in group I and 38/57 (66.7%) patients in group II received invasive mechanical ventilation support (p <0.05). The mortality rate of patients without AKI development was higher in group II [ 22/40 (55%)] than group I [19/61 (31.2%)] (p<0.05). Conclusion: It was determined that the development of acute kidney injury in patients with critical illness and variant B.1.1.7 infection followed was less than in the other patients. This result suggested that the increase in mortality in variant B.1.1.7 infection occurred independently of the development of acute kidney injury.

Keywords:

COVID-19, variant B.1.1.7, acute kidney injury, mortality,

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