Erişkin epilepsi hastalarında insülin direnci ve obezitenin değerlendirilmesi

Amaç: Epilepsi kronik bir hastalıktır. Epilepsi hastalarında inme, diabet, kalp hastalığı, hipertansiyon, tiroid bozukluğu, migren, anksiyete ve depresyon gibi komorbid durumların normal popülasyona göre daha sık karşılaşıldığı bildirilmiştir. Bizim bu çalışmadaki amacımız epilepsi hastalarında insülin direnci ve obezite varlığını araştırmaktır.Materyal ve Metod: Çalışmaya Harran Tıp Fakültesi Nöroloji Poliliniğinden takipli 100 epilepsi hastası ve 45 sağlıklı kontrol alındı. Hastaların yaşı, cinsiyeti, hastalığının süresi, nöbet tipi, nöbet sıklığı, antiepileptik tedavisi incelendi.Bulgular: Hastaların 51’si (%51) erkek, 49’u (%49) kadın idi. Hastaların yaş ortalaması 27.12 ± 9.46, hastalık süresinin ortalaması 12 ± 9.52 idi. Epilepsi hasta grubunda, sağlıklı kontrol grubuna göre insülin direnci ve ortalama vücut kitle indeksi anlamlı olarak daha yüksek idi. Yine epilepsi hastalarında, sağlıklı kontrollere göre obezite anlamlı olarak daha fazla idi. Kontrollü epilepsi ile dirençli epilepsi grubu ve monoterapi ile politerapi alan gruplar arasında vücut kitle indeksi, serum insülin seviyesi ve insülin direnci açısından istatiksel olarak anlamlı bir ilişki saptanmadı. Sonuç: Epilepsi hastalarında normal popülasyona göre ortalama insülin direnci değerleri ve obezite anlamlı olarak daha fazla idi. Epilepsi hastalarında, insülin direnci ve kilo alımının yakın takibi ve erken dönemde önlem alınması, bu faktörlere bağlı gelişebilecek metabolik sendrom, kognitif etkilenme, inme ve kardiovasküler hastalıkların önlenmesi açısından önemlidir

Anahtar Kelimeler:

Epilepsi, Obezite, Vücut kitle indeksi

Evaluation of insulin resistance and obesity in adult epileptic patients

Aim: Epilepsy is a chronic disease. It has been reported that comorbid conditions such as stroke, diabetes, heart disease, hypertension, thyroid disorder, migraine, anxiety and depression are more common in epilepsy patients than in the normal population. Our aim in this study is to investigate the presence of insulin resistance and obesity in epileptic patients.Material and Methods: The study included 100 epileptic patients who were admitted to Harran Medical Faculty Neurology Policlinic and 45 healthy controls Age, gender, duration of illness, seizure type, seizure frequency, antiepileptic treatment were studied.Results: 51 (51%) of the patients were male and 49 (49%) were female. The mean age of the patients was 27.12 ± 9.46 and the mean duration of illness was 12 ± 9.52. In the epilepsy group, mean insulin resistance and mean body mass index were significantly higher than in the healthy control group. Also, in epileptic patients, obesity was significantly higher than healthy controls. There was no statistically significant relationship between controlled epilepsy and resistant epilepsy group and between monotherapy and polytherapy groups in terms of body mass index, serum insulin level and insulin resistance. Conclusion: The mean insulin resistance values and obesity were significantly higher in the epilepsy patients than in the normal population. In epileptic patients, close follow-up of weight gain and insülin resistance and early prevention are important in terms of prevention of metabolic syndrome, cognitive impairment, stroke and cardiovascular diseases that may be caused by these factors.

Keywords:

Epilepsy Obesity, Body mass index, Insulin resistance,

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