Alihan BOZOĞLAN, Mehmet GÜL, Serkan DÜNDAR

Enamel Matris Türevinin (Emdogain®) Dental İmplant Osseointegrasyonu Üzerindeki Etkilerinin Değerlendirilmesi

Amaç: Bu çalışmanın amacı, Enamel matris türevinin (Emdogain®) kemik grefti ile karıştırılarak defekt oluşturulan bölgeye uygulanmasından sonra yeni kemik rejenerasyonunun kemik implant kaynaşmasına etkisinin değerlendirilmesidir. Materyal ve metod: Deneyde toplamda 20 adet sprague dawley rat kullanılmıştır. Herbir grupta 10 adet rat bulunmaktadır. Ratlar, % 55’lik nem ve 22 ±2°C sıcaklık kontrollü bulunan odada bulundurulmuştur. Ayrıca 12 saat aydınlık 12 saat karanlık döngüsünde tabi tutulmuştur. Deneklerin sağ tibiya kemiklerinin metafiziyel kısımlarındaki kortikokansellöz kemiğine kaviteler açıldı. Bu kavitelere 2.5 mm çapında 4 mm uzunluğundaki titanyum implantlar yerleştirildi ve boyun bölgesinde implant boyunun 2 mm’sine tekabül edecek şekilde kontrol grubuna sadece kemik defekti yerleştirildi. Deney grubuna ise kemik grefti ve Enamel matris türevinin (Emdogain®) yerleştirildi. 8 hafta sonra denekler sakrifiye edildi. Bulgular: Yapılan analizler sonucunda kemik implant kaynaşması emdogain uygulanan grupta yüksek bulunmasına rağmen istatistiksel olarak anlamlı bir fark elde edilememiştir. Aynı şekilde glukoz, ast, alt, alp, üre, kreatinin ve kalsiyum seviyeleri değerlendirilmiş ve istatistiksel olarak anlamlı bir fark elde edilememiştir. Fakat fosfor seviyesinde deney grubunda anlamlı derece bir düşme tespit edilmiştir (p < 0.05). Sonuç: Emdogain uygulaması greft materyalinin etkisini artırmaktadır ve aynı zamanda implant kemik kontağına olumlu etkisi bulunmaktadır. Fakat 8 haftalık kısa iyileşme periyodunda etkisi sınırlı olmaktadır. Emdogain uygulamasının etkisinin kesin olarak anlaşılması için uzun zamanlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

dental implant, kemik grefti, Emdogain

Evaluation of the Effects of the Enamel Matrix Derivative (Emdogain®) on Dental Implant Osseointegration

Background: The aim of this study is to evaluate the effect of new bone regeneration on bone implant fusion after the Enamel matrix derivative (Emdogain®) is mixed with bone graft and applied to the defect area. Materials and Methods: A total of 20 sprague dawley rats were used in the experiment. There are 10 rats in each group. Rats were kept in a room with 55% humidity and 22 ± 2 ° C temperature controlled. It was also subjected to a 12 hour light and 12 hour dark cycle. Cavities were opened in the corticocancellous bone in the metaphyseal parts of the right tibia bones of the subjects. Titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in these cavities, and only a bone defect was placed in the control group, corresponding to 2 mm of the implant length in the neck region. Bone graft and Enamel matrix derivative (Emdogain®) were placed in the experimental group. After 4 weeks, the subjects were sacrificed. Results: As a result of the analysis, although bone implant fusion was found to be high in the emdogain group, no statistically significant difference was found. Likewise, glucose, ast, alt, alp, urea, creatinine and calcium levels were evaluated and no statistically significant difference was found. However, a significant decrease was detected in the phosphorus level in the experimental group (p <0.05). Conclusions: Emdogain application increases the effect of the graft material and also has a positive effect on implant bone contact. However, its effect is limited in the short recovery period of 8 weeks. Long-term studies are needed to fully understand the effect of Emdogain administration.

Keywords:

dental implant, bone graft, Emdogain,

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