İrfan KOCA, Mehmet UCAR, Ahmet TUTOGLU, Ayse BERHOGLU, Ahmet BOYACİ

Düşük doz Methotrexatın indüklediği Henoch-Schönlein Purpurası

Metotreksat (MTX), çeşitli malignite ve kronik inflamatuvar hastalıkların tedavisinde kullanılan antiproliferatif bir folik asit antagonistidir. Düsük doz, haftalık MTX tedavisi alan hastalarda sık görülen yan etkiler bulantı ve stomatittir. Henoch-Schönlein purpurası (HSP) genellikle, infeksiyon ajanları, soğuk, böcek ısırması, besinler veya ilaçlara bağlı olarak tetiklenir. Bu yazıda juvenil idiyopatik artrite yönelik düşük doz metotrexate başlanan 14 yaşındaki erkek hastada tedavinin 3. haftasında ortaya çıkan HSP literatür eşliğinde sunulmuştur.

Anahtar Kelimeler:

Henoch-Schönlein Purpura, Juvenile Idiopathic Artrit, Metotreksa

Henoch-Schönlein Purpura induced by Low-Dose Methotrexate

Methotrexate (MTX) is an antiproliferative folic acid antagonist used in the treatment of various malignancies and chronic inflammatory diseases. Commonly observed side effects in patients receiving lowdose, weekly MTX treatment are nausea and stomatitis. Henoch-Schönlein purpura (HSP) is a condition generally induced by infectious agents, exposure to cold, insect bites, foods, and drugs. In this paper, we presented together with a review of the literature a case of HSP that developed in the third week of treatment of a 14-year-old male patient started on low-dose methotrexate for juvenile idiopathic arthritis.

Keywords:

Henoch-Schönlein Purpura, Juvenile Idiopathic Arthritis, Methotrexate,

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