Poli(hidroksietil metakrilat-N-metakrilo-L-Histidin metil ester) Temelli Kriyogel ile Beta talasemili İnsan Plazmasından$Fe^{3+}$’ün Uzaklaştırması

Bu çalışmada, $Fe^{3+}$ adsorpsiyonu, süpermakrogözenekli poli(2-hidroksietil metakrilat-N-metakrilo-(I)-histidin metil ester) [poli(HEMA-MAH)] kriyojeli kullanılarak incelenmiştir. Poli(HEMA-MAH) kriyojeli elektron mikroskop taraması ve şişme testleriyle karakterize edilmiştir. Akış hızı, pH, $Fe^{3+}$’ün başlangıç derişiminin $Fe^3$ adsorpsiyonuna etkileri incelenmiştir. Poli(HEMA-MAH) temelli kriyojelin denge şişme derecesi 7.54 g $H_2$0/g kriyojel olarak bulunmuştur. Poli(HEMA-MAH) temelli kriyojelin $Fe^{3+}$ adsorpsiyon kapasitesi 1.71 mg/g bulunmuştur. Önemli miktarda adsorpsiyon kapasitesi kaybı olmadan $Fe^{3+}$ iyonlarının P(HEMA-MAH) kriyojel ile adsorbe ve desorbe edildiği saptanmıştır.

Poly(hydroxyethyl methacrylate)-co-N-methacryloyl-(L)- histidine methyl ester Based Cryogel for the Removal of $Fe^{3+}$ from Human Plasma effected with Beta Thalassemia

In this study, $Fe^{3+}$ adsorption was carried by using supermacroporous poly(2-hydroxyethyl methacrylate-Nmethacryloyl-(L)-histidine methyl ester) [poly(HEMA-MAH)] cryogel. Poly(HEMA-MAH) cryogel was characterized by swelling tests and scanning electron microscopy. The influence of flow rate, pH, initial $Fe^{3+}$ concentration, and $Fe^{3+}$ adsorption from human plasma effected with beta thalassemia on the adsorption efficiency of the cryogel was investigated. The equilibrium swelling degree of poly(HEMA-MAH) cryogel was found to be 7.54 g $H_2$O/g cryogel.$Fe^{3+}$ adsorption capacity of poly(HEMA-MAH) cryogel from aqueous solution was estimated as 1.79 mg/g cryogel, while lower adsorption capacity was observed in human plasma (1.71 mg/g). It was also observed that $Fe^{3+}$ could be repeatedly adsorbed and desorbed using poly(HEMA-MAH) cryogel without significant loss in its adsorption capacity.

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