Hasan Erdinç SELLİTEPE, İnci Selin DOĞAN, Bahittin KAHVECİ

Bazı Ester Etoksikarbonil Hidrazonların 1-Adamantil Amin ile Reaksiyonlarının Araştırılması

Bu çalışmada, 1-adamantil amin bileşiğinin 4 farklı ester etoksikarbonil hidrazon türevi ile reaksiyonu incelenmiştir. İlk olarak, iminoester hidroklorür türevleri Pinner yöntemine göre sentezlendi. Daha sonra, ester etoksikarbonil hidrazon türevi bileşiklerinin sentezlenmesi için etil karbazat ile reaksiyona sokuldu. Son basamakta, 3-sübstitüe-4-adamantil-1,2,4- triazol-5-on türevlerinin sentezlenmesi amaçlandı, ester etoksikarbonil hidrazin türevli bileşikler 1-adamantil amin ile bir yağ banyosunda kuru kuruya ısıtıldı. Ancak, IR ve ¹H-NMR analizleri ile halkanın kapanmadığı anlaşıldı ve etil N- (adamantilkarbamoil)alkilkarbohidrazonoat türevi bileşiklerin stabil ve orijinal bileşikler olarak sentezlendiği gözlenmiştir. Sentezlenen bileşiklerin yapısı, IR, ¹H-NMR, 13C-NMR spektrumları ve LC/MS analizi gibi spektroskopik yöntemlerle kanıtlandı.

Investigation of Reaction of Some Ester Ethoxycarbonyl Hydrazones with 1-Adamantyl Amine

In this study, the reactions of the 1-adamantyl amine with 4 different ester ethoxycarbonyl hydrazone derivatives werestudied. At first, iminoester hydrochloride derivatives were synthesized according to the Pinner method. Then theywere reacted with ethyl carbazate to synthesize ester ethoxycarbonyl hydrazone derivative compounds. In the last step,3-substituted-4-adamantyl-1,2,4-triazol-5-one derivatives were aimed to synthesize, the ester ethoxycarbonyl hydrazonecompounds were heated in an oil bath dry to dry with 1-adamantyl amine. It has been observed, however, that the ring isnot closed according to IR and ¹H-NMR analysis and the ethyl N-(adamantylcarbamoyl)alkylcarbohydrazonoate derivativecompounds were synthesized as stabile and original compounds. The structures of the synthesized compounds were elucidated by spectroscopic methods using IR, ¹H-NMR, 13C-NMR spectra and LC/MS analysis.

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