Tolga Altuğ ŞEN, Ayşegül BÜKÜLMEZ, Ramazan ALBAYRAK, Bumin DEĞİRMENCİ, Tevfik DEMİR, Reşit KÖKEN, Hamide MELEK, Murat ACAR

Tip 1 diabetes mellituslu çocukların retinal doppler ultrasonografi bulguları ve homosistein düzeyleri

Amaç: Tip 1 diyabetli çocuklarda diyabetik retinopatiyle ilişkili oldukları düşünülen plazma homosistein düzeylerinin ölçülmeleri, retinal arterlerdeki kan akım hızlarının Doppler ultrasonografiyle değerlendirilerek sağlıklı çocukların ölçümleriyle kıyaslanmaları için bu çalışma planlanmıştır.Gereç ve Yöntem: Çalışmamız için tip 1 diyabet tanısıyla izlenen yaşları 8-18 (Ortalama 13,2±4,3) arasında olan, 42 hasta (22 kız, 20 erkek) seçilmiştir. Tip 1 diyabet tanılı çocukların ortalama hastalık süreleri 5,02±2,99 yıldır. Kontrol grubu için yaşları 9-18 (Ortalama 14,01±3,5) arasında olan 30 çocuk (15 erkek, 15 kız) seçilmiştir. Vakaların santral retinal arter ve oftalmik arterlerinden pik sistolik hız, diyastolik hız, rezistivite indeksi ve pulsatilite indeksi ölçümleri yapılmıştır.Bulgular: Tip 1 diyabetli çocuklarla kontrol grubundaki çocuklar arasında sadece santral retinal arter diyastolik hızları için, iyi ve kötü kontrollü tip 1 diyabetli çocukların arasında ise sadece oftalmik arter Vmax ölçümleri için anlamlı farklılıklar bulunurken (p0,05). Kötü metabolik kontrollü tip 1 diyabetli hastaların oftalmik arter rezistivite indeksleri (0,82±0,04), iyi metabolik kontrollü tip 1 diyabetli hastaların rezistivite indekslerine göre (0,76±0,08) daha yüksek bulunmuştur. Tip 1 diyabet tanılı çocukların ortalama homosistein düzeylerinin (10,3±2,18 mmol/L), kontrol grubundaki çocuklara (9,12±1,9 mmol/L) göre daha yüksek, kötü kontrollü tip 1 diyabetli çocukların ortalama homosistein düzeylerinin (11,33±2 ,05 mmol/L) iyi kontrollü çocuklara (9,42±2,12 mmol/L) göre daha yüksek olduğu ve aradaki farkların anlamlı olduğu tespit edilmiştir (p

Retinal doppler ultrasound and homocystein levels in children with type I diabetes mellitus

Aim: We aimed to measure plasma homocysteine levels and retinal arterial blood flow of type 1 diabetic children by Doppler ultrasound, which were known to be related with diabetic retinopathy and to compare them with healthy children.Materials and Methods: We selected 42 diabetic children (22 females, 20 males), between the ages of 8 to18 years (mean 13,2±4,3). Mean duration of type 1 diabetes was 5,02±2,99 years. For the control group, 30 children (15 females, 15 males) between the ages of 9 to 18 years (mean 14,01±3,5) were selected. In central retinal arteries and ophthalmic arteries, peak systolic velocity, diastolic velocity, pulsatility and resistivity indexes were measured.Results: Except for the higher central retinal artery diastolic velocity in the control group, retinal blood flow velocities were similiar in diabetic children and the control group (p0,05). Mean ophthalmic artery peak systolic velocity (37,33±12,79 cm/sec) for well controlled diabetic children was higher than the poorly controlled group (31,1±17,17 cm/sec); mean ophthalmic artery resistivity index (0,76±0,08) for well controlled group was lower than the mean resistivity index (0,82±0,04) of poorly controlled group. Plasma homocysteine levels were higher in diabetic children (10,3±2,18 mmol/L) than the control group (9,12±1,9 mmol/L) (p

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