Borik Asitin 8305C Anaplastik Tiroit Kanseri Hücrelerinde Antioksidan ve Anti-kanser Aktivitesi

Bu çalışmanın amacı, borik asitin 8305C insan anaplastik tiroit kanseri (ATK) hücrelerinde sitotoksik, anti-proliferatif, apoptotik ve antioksidan etkilerini değerlendirmektir. Borik asitin sitotoksisitesi 0-1000 μg/mL doz aralığında (24, 48 ve 72 saat) 8305C insan ATK hücrelerinde bir tetrazolyum testiyle (MTT) belirlendi. Hücrelerdeki proliferasyon ve apoptoz incelendi. Biyokimyasal parametreler spektrofotometrik olarak tespit edildi. 24, 48 ve 72 saat borik asit ile muamele edilen 8305C insan ATK hücrelerinin yarı-maksimum inhibisyon konsantrasyon (IC50) değerleri sırasıyla 238 µg/mL, 116 µg/mL ve 70 µg/mL olarak hesaplandı (p

Anahtar Kelimeler:

Apoptoz, Borik Asit, Kanser, Proliferasyon, Troit.

Antioxidant and Anti-cancer Activity of Boric Acid in 8305C Anaplastic Thyroid Cancer Cells

anti-proliferative, apoptotic and antioxidant effects of boric acid in 8305C human anaplastic thyroid cancer (ATC) cells. The cytotoxicity of boric acid was determined at a dose range of 0-1000 μg/mL in the human ATC cells (24, 48, and 72 hours) by a tetrazolium test (MTT). Proliferation and apoptosis in the cells were examined. Biochemical parameters were determined spectrophotometrically. The half-maximal inhibitory concentration (IC50) values of cells treated with boric acid for 24, 48, and 72 hours were calculated as 238 µg/mL, 116 µg/mL, and 70 µg/mL, respectively (p

Keywords:

Apoptosis, Boric Acid, Cancer, Proliferation, Thyroid.,

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