Murat Turgay, Demet Menekse Gerede Uludağ, Kerim Esenboğa, Sina Aliielkhchi, Mustafa Kılıçkap

Sklerodermalı hastalarda karotis intima-media kalınlığı ile subklinik aterosklerozun değerlendirilmesi

Amaç: Enflamasyon ateroskleroz gelişiminde önemli bir role sahiptir. Enflamatuvar aktivitenin yüksek olduğu sistemik lupus eritematozus ve romatoid artrit gibi hastalıkları olan hastalarda ateroskleroz ve ateroskleroza bağlı gelişebilecek komplikasyon riski sağlıklı bireylere göre daha yüksektir. Bununla birlikte, birkaç çalışma sklerodermalı hastalarda çelişkili sonuçlar göstermiştir. Bu çalışmada karotis intima-media kalınlığı (KİMK) kullanılarak sklerodermalı hastalar ve kontrol grubu karşılaştırıldı. Yöntemler: Çalışmaya skleroderma tanısı konan 30 hasta (ortalama yaş 51.3 ± 11.8 yıl) ve 30 sağlıklı gönüllü dahil edildi. Gruplar yaş, cinsiyet ve ateroskleroz için risk faktörleri açısından benzerdi. Bulgular: Gruplar arasında yaş, cinsiyet, lipid düzeyi, hipertansiyon ve diabetes mellitus prevalansı açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Ortalama KİMK (skleroderma grubu: 0.070±0.011, kontrol grubu: 0.048±0.008, p

Anahtar Kelimeler:

ateroskleroz, enflamasyon, karotis intima-medya kalınlığı, skleroderma

Assessment of subclinical atherosclerosis with carotid intima-media thickness in patients with scleroderma

Aim: Inflammation has an important role in the development of atherosclerosis. The risk of atherosclerosis and its complications is higher for patients with diseases such as systemic lupus erythematosus and rheumatoid arthritis in whom inflammatory activity is high than for healthy individuals. However, several studies have shown conflicting results in patients with scleroderma. In this study, carotid intima-media thickness (CIMT) was compared in patients with scleroderma and a control group. Methods: Thirty patients diagnosed with scleroderma (mean age 51.3 ± 11.8 years) and 30 healthy volunteers were included in the study. The groups were similar regarding age, gender, and risk factors for atherosclerosis. Results: There was no statistically significant difference between the groups regarding age, gender, lipid level, hypertension, and diabetes mellitus prevalence (p>0.05). The mean CIMT (scleroderma group: 0.070±0.011, control group: 0.048±0.008, p

Keywords:

atherosclerosis, carotid intima-media thickness, inflammation, scleroderma,

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