Pubert Prekoks ve Prematur Telarş Sıklığının artmasında COVID-19 pandemi sürecinin etkisinin değerlendirilmesi

Amaç: Bu çalışmada amaç; COVID-19 pandemi sürecinin santral puberte prekoks (SPP) ve prematur telarş(PT) sıklığının artış ve ilişkisini araştırmaktır. Gereç ve Yöntem: Çocuk Endokrinoloji polikliniğine başvuran 60 kız hasta çalışmaya dahil edildi. Hastaların ilk başvuru anamnez ve fizik muayene bulguları, kemik yaşı, serbest T4, TSH, folikül stimüle edici hormon (FSH), lüteinize edici hormon (LH), estradiol (E2), düzeyleri kaydedildi. Gerekli olgularda yapılmış olan luteinize edici hormon releasing hormon (LH-RH) testi sonucuna göre PT ve SPP olarak ayrıldı. Pandemi öncesi ve sırasında teknolojik araçların kullanımındaki farklılıklar kayıt edildi. Bulgular: Santral puberte prekokslu olgularda daha yüksek vücut kitle indeksi (VKİ)(P=0.034), kemik yaşı (p<0.001), bazal LH (P<0.001), bazal FSH(P<0.001), bazal estradiol (P<0.001) düzeyi tespit edildi. Yaş ve kilo bakımından her iki grup arasında farklılık yoktu. Her iki grupta da pandemi öncesine göre kıyaslandığındateknolojik araçların (akıllı telefon, bilgisayar, televizyon)kullanımında belirgin artış vardı. Prematur telarşı olan olgularda pandemi öncesinde 2,54 ±0,65 saat/gün pandemi sırasında 6,22±1,25 saat/ gün idi (p<0,001). SPP’li olgularda pandemi öncesinde 2,7 ±0,46 saat/gün pandemi sırasında 7,36±1,36 saat/gün idi (p<0,001). Teknolojik araçların kullanımının ana sebebi okul dersleri idi (PT olan olgularda 4,6 ± 1,2 saat/gün, SPP’ li olgularda 5±1,2 saat/gün p=0,393). Sonuç: Çalışmamızda her iki grubumuzda da pandemi sonrasında teknolojik alet kullanımında belirgin artış olduğu görüldü. Ayrıca santral puberte prekoks başlangıç yaşının erkene kaydığını saptandı. Kilo, elekronik aletlerin kullanımın artışı gibi çevresel faktörlerin ergenlik başlangıcını ve ilerleyiş hızını tetiklediğini düşünüldü.

Anahtar Kelimeler:

Puberte Prekoks, Puberte Prekoks, koronavirus, pandemik

Evaluation of the COVID-19 pandemic process effect on the increase of Precocious Puberty and Premature Thelarche

Objective :To determinate COVID-19 pandemic process effect on the increase of Precocious Puberty and Premature Thelarche Material and Methods: Total 60 girls, younger than 8 years old, who complaint with breast development. Medical history and physical examination findings, bone age, free T4, TSH, FSH, LH, estradiol levels of patients were recorded in their first visits. According to LHRH test results patients were divided to subgroups such as PT and CPP. Differences in the use of technological tools were recorded before and during the pandemic Results: Higher Body Mass Index (BMI) (P=0.033), bone age (P<0.001) basal LH (P<0.001), basal FSH (P<0.001), basal estradiol (P<0.001) in cases with central puberty precocious level was detected. There was no difference between the two groups in terms of age and weight. Compared to the pre-pandemic period, there was a significant increase in the use of technological tools (smartphone, computer, television) in both groups. In cases with PT, it was 2.54 ±0.65 hours/day before the pandemic and 6.22±1.25 hours/day during the pandemic (p<0.001), in cases with Spp it was 2.7 ±0.46 hours/day before the pandemic, 7.36±1.36 hours/day during the pandemic (p<0.001). The main reason for using technological tools was school lessons (4.6 ± 1.2 hours/day in cases with Pt, 5±1.2 hours/day in cases with Spp p =0.393). Conclusion: In our study, it was observed that there was a significant increase in the use of technological devices and puberty symptoms started at a younger age in both groups after the pandemic. It was thought that environmental factors such as weight and increased use of electronic devices triggered the onset of puberty and the rate of progression.

Keywords:

Precocious Puberty, Coronavirus, pandemic,

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