Psöriasis hastalarında psöriatik artrit görülme sıklığı ve psöriatik artritin klinik özellikleri

Amaç: Psöriatik artrit (PsA), çoğunlukla psöriasis ile birlikte görülen yaygın inflamatuvar ve sistemik bir hastalıktır. Bu çalışmada psöriasis tanısıyla takip edilen hastalarda PsA sıklığı ve klinik özelliklerinin tespit edilmesi amaçlandı.Gereç ve Yöntem: Çalışmada 32 psöriasis hastasının dosyası retrospektif olarak tarandı. Klinik ve sosyodemografik özellikler kaydedildi. Hastalar Classification criteria for psoriatic arthritis (CASPAR) kullanılarak PsA açısından değerlendirildi.Bulgular: 15 hastada (46,8%) PsA tespit edildi. Kadın hasta sayısı ve psöriasis süresi PsA bulunan grupta bulunmayanlara göre daha fazlaydı (p

Objective: Psoriatic arthritis (PsA) is a common inflammatory dermatological disease which may be complicated with joint involvement. The aim of this study was to evaluate the frequency and clinical characteristics of PsA in patients with psoriasis.Material and Methods: : Thirty two hospital charts which belong to psoriasis patients were retrospectively evaluated. Clinical and sociodemographic characteristics were recorded. The patients were examined for PsA according to Classification criteria for psoriatic arthritis (CASPAR).Results: PsA was determined in 15 (46.8%) patients. Female gender and duration of psoriasis were higher in group with PsA (p<0.05). Low back pain was determined in all patients in group with PsA. The rate of HLA-B27 positivity was 33% of patients with PsA. The rate of sacroileitis was 55.7% of patients with PsA.Conclusions: PsA in patients with psoriasis is a common disease. Female gender, duration of psoriasis, HLA-B27 positivity and sacroileitis may be risk factors for PsA. Further studies including a larger sample size are needed to confirm these results.

___

  • 1. Sperling L. Alopecias. In: Bolognia J, Jorizzo J, Rapini R, eds. Dermatology. New York: Mosby Elsevier; 2008: 992-5.
  • 2. Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549-566; quiz 567-70.
  • 3. Van der Steen P, Traupe H, Happle R, Boezeman J, Sträter R, Hamm H. The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol 1992; 72(5):373-5.
  • 4. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012 26;5(1):2.
  • 5. Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9.
  • 6. Ozturk ZA, Kuyumcu ME, Yesil Y, et al. Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients? J Endocrinol Invest 2013;36:593-9.
  • 7. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218-30.
  • 8. Ahsen A, Ulu MS, Yuksel S, et al. As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio. Inflammation 2013;36:1357-62.
  • 9. Celikbilek M, Dogan S, Ozbakır O, et al. Neutrophil- lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013;27:72-6.
  • 10. Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Mater Sociomed 2014;26:231-3.
  • 11. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;33:223.
  • 12. Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: Part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010;62:177- 88.
  • 13. Matzer F, Egger JW, Kopera D. Psychosocial stress and coping in alopecia areata: a questionnaire survey and qualitative study among 45 patients. Acta Derm Venereol 2011;91:318-27.
  • 14. Ozlu E, Karadag AS, Akdeniz N, Uzuncakmak TK. Acitretin-induced alopecia areata: a case report. Cutan Ocul Toxicol 2015;34:248-50.
  • 15. ong J, Lim SW. Alopecia areata as a paraneoplastic syndrome of Hodgkin's lymphoma: A case report. Mol Clin Oncol 2014;2:596-8.
  • 16. Qiao J, Zhou G, Ding Y, Zhu D, Fang H. Multiple paraneoplastic syndromes: myasthenia gravis, vitiligo, alopecia areata, and oral lichen planus associated with thymoma. JNeurol Sci 2011;308:177-9.
  • 17. Rifaioglu EN, Şen BB, Ekiz O, Dogramaci AC. Neutrophil to lymphocyte ratio in Behçet's disease as a marker of disease activity. Acta Dermatovenerol 2014;23:65-7.
  • 18. Li L, Xia Y, Chen C, Cheng P, Peng C. Neutrophil-lymphocyte ratio in systemic lupus erythematosus disease: a retrospective study. International Journal of Clinical and Experimental Medicine 2015;8:11026-31.
  • 19. Paramanathan A, Saxena A2, Morris DL3. A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol 2014; 23:31-9.
  • 20. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002;105:2462-4.
  • 21. Yousefi M, Namazi MR, Rahimi H, Younespour S, Ehsani AH, Shakoei S. Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata. Indian J Dermatol 2014; 59:630.
  • 22. Kalish RS, Johnson KL, Hordinsky MK. Alopecia areata. Autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood. Arch Dermatol 1992;128:1072- 7.
Genel Tıp Dergisi-Cover
  • ISSN: 2602-3741
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1997
  • Yayıncı: SELÇUK ÜNİVERSİTESİ > TIP FAKÜLTESİ