Ümit ŞENER, Mehmet Emin YANIK, Mustafa ERBOĞA, HÜLYA ALBAYRAK, Gamze ERFAN, Ahmet GÜREL

Alopesi Areatalı hastaların hematolojik parametrelerinin normal populasyon ile karşılaştırılması

Amaç: Bu çalışmada, alopesi areatalı hastaların hematolojik parametrelerinin normal populasyonun hematolojik parametreleri ile karşılaştırılması ve olası değişikliklerin, farklılıkların saptanması amaçlanmıştır.Yöntem: Bu çalışma, geriye dönük olarak gerçekleştirildi. 2013-2015 Yıllarında Namık Kemal Üniversitesi, Araştırma ve Uygulama Merkezi, Deri ve Zührevi Hastalıklar Polikliniği'ne başvurmuş 18-65 yaş arasındaki, 50 (35 erkek, 15 kadın) Alopesi Areata tanısı almış hasta, 50 (35 erkek, 15 kadın) sağlıklı kontrol, çalışmaya dahil edildi. Hastalara ve kontrol grubuna ait hematolojik parametreleri, kayıtlardan öğrenildi. Bulgular: AA' lı hastalara ait eritrosit sayısı (RBC), hemoglobin miktarı (Hb), hematokrit (Htc) değerleri, total lökosit, nötrofil, lenfosit ve monosit sayılarının kontrol grubuna göre anlamlı derecede yüksek, eritrosit dağılım aralığı (RDW-CV) değerinin ise anlamlı derecede düşük olduğu görüldü (sırasıyla p

Objective: To compare hematological parameters in patients with alopecia areata (AA) and in a normal population sample in order to detect potential differences between these two groups. Methods: This was a retrospective study conducted between 2013 and 2015 involving a total of 50 patients diagnosed with alopecia areata (35 male, 15 female) and 50 healthy controls (35 male, 15 female) between 18 and 65 years of age. Hematological parameters of patient and control subjects were retrieved from medical records. Results: Patients with AA had significantly higher red blood cell (RBC) count, hemoglobin (Hb), and hematocrit (Htc) values as well as total leukocyte, neutrophil, and monocyte counts as compared to controls; on the other hand the red blood cell distribution width (RDW-CV) was significantly lower among those with AA (p<0.05, p<0.01, p<0.01, p<0.05, p<0.05, p<0.05, p<0.05, and p<0.001 respectively). RDW-CV was significantly lower in both males and females with AA as compared to controls (p<0.05, and p<0.01, respectively). Males with AA had significantly higher Hb and Htc in comparison with male controls (p < 0.01 for both); similarly, significantly higher total leukocyte, neutrophil, lymphocyte and monocyte counts were found in male AA patients than in control males (p<0.01, p<0.05, p<0.01, and p<0.05, respectively). Conclusion: The changes observed in erythrocyte and leukocyte cell lines in patients with AA as compared to controls suggest an increased activity both in hematopoiesis and cellular immunity. Also, they suggest the presence of factors that may stimulate hematopoiesis in AA patients as well as the presence of an immune activation, indicating that autoimmune processes may play a role in the etiology of this condition. Further studies are warranted to support our observations.

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1. Goh C, Finkel M, Christos P, et al. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. Journal of the European Academy of Dermatology and Venereology 2006;20:1055-60.

2. Wasserman D, Guzman-Sanchez DA, Scott K, et al. Alopecia areata. Int J Dermatol. 2007;46:121-31.

3. McMichael AJ. The genetic epidemiology and autoimmune pathogenesis of alopecia areata. Journal of the European Academy of Dermatology and Venereology 1997;9:36-43.

4. Erkin EF, Güler C, Kayıkçıoğlu Ö, et al. Diabetik Retinopati ile Hematolojik Parametrelerin İlişkisi. RetinaVitreus.2001;9:45-9.

5. Serilmez M, Soydinç HO, Çamlıca H, et al.. Akciğer kanserinde hematolojik parametreler. Türk Onkoloji Dergisi 2010;25:87-92.

6. Atsü AN, Karakayalı G, Allı N, et al. Alopesi Areatalı Hastalarda Hemoglobin, Hematokrit ve Serum Ferritin Düzeyleri. Turkiye Klinikleri Journal of Dermatology 1998;8:121-4.

7. Donma O, Donma MM, Nalbantoglu B, et al. The Importance of Erythrocyte Parameters in Obese Children. International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering 2015;9:351-4.

8. Tülübaş F, Oran M, Mete R, et al. İrritabl Bağırsak sendromlu Hastalarda Eritrosit ve Trombosit Hücre Sayılarının Değerlendirilmesi. International Journal of Basic and Clinical Medicine 2014;1:1.

9. Wu T, Chuang L, Tai T. Erythrocyte deformability in diabetes mellitus. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association. 1989;88:240-3.

10. White M, Currie J, Williams M. A study of the tissue iron status of patients with alopecia areata. British Journal of Dermatology 1994;130:261-3.

11. Boffa M, Wood P, Griffiths C. Iron status of patients with alopecia areata. British Journal of Dermatology 1995;132(4):662-4.

12. Atwa MA, Youssef N, Bayoumy NM. T-helper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factor-?) in patients with alopecia areata: association with clinical type and severity. Int J Dermatol 2016;55:666-72.

13. Dobreva A, Paus R, Cogan NG. Mathematical model for alopecia areata. Journal of Theoretical Biology 2015;380:332- 45.

14. Aydın M, Akyüz A, Alpsoy Ş, et al. Nötrofil Lenfosit Oranının Kalp Hızı Toparlanma İndeksi İle İlişkisi. Int J Basic Clin Med 2013;1:107-111.

15. Taylan M, Demir M, Kaya H, et al. Alterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients. Clin Respir J 2015; doi: 10.1111/crj.12336.

16. Lou M, Luo P, Tang R, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord 2015 Mar 2;15:9. doi: 10.1186/s12902-015-0002-9.

17. Göçmen H, Hikmet Ç. KOAH Akut Atakta Serum CRP Düzeyi ve Hematolojik Parametreler ile Hastalık Şiddeti Arasında Korelasyon Var mı ? Solunum Hastalıkları 2007;18:141-7.