Serkan YILDIRIM, Banu Pınar ŞARER YÜREKLİ

Kronik Lenfositik Tiroiditli Olgular ve Normal Populasyonda D Vitamini Düzeylerinin Karşılaştırılması ve Otoimmünite Üzerindeki Rolü

Amaç D vitamini eksikliğinin otoimmün hastalıklar, inflamatuar bağırsak hastalığı, romatoid artrit, multipl skleroz, diyabet, birçok kanser türü ve kalp hastalıklarının oluşumunda rolü olduğu bilinmektedir. Bu çalışma, D vitamininin Hashimoto tiroiditindeki rolünü göstermek için yapılmıştır. Gereç ve Yöntem Bu kesitsel çalışmaya 16-50 yaş aralığında İzmir Bozyaka Eğitim ve Araştırma Hastanesi endokrinoloji polikliniğine başvuran ultrasonografik olarak kronik tiroidit ile uyumlu ,serolojik olarak antikor pozitif (anti T, anti M) ,ötiorid ,beden kütle indeksi (BKİ) < 30 olan menapoza girmemiş , herhangi başka ek bir hastalığı ve kronik ilaç kullanımı olmayan 40 Hashimoto tiroditli kadın hasta ile yine İzmir Bozyaka Eğitim ve Araşatırma Hastanesi dahiliye veya endokrinoloji polikliniklerine başvurmuş olan 16-50 yaş aralığında beden kütle indeksi (BKİ) <30 olan 40 sağlıklı, tiiroid antikorları negatif kadın hasta alındı. Obezitenin D vitamini-hormonu ile negatif ilişkisi daha önceden yapılan çalışmalarda gösterilmiş olduğundan çalışmamıza beden kütle indeksi (BKİ) >30 olan Hashimoto tiroiditli veya sağlıklı gönüllüler alınmamıştır. Bulgular İki grup yaş, vücut kitle indeksi, t3, t4, TSH, Anti M, Anti T ve D vitamini açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulunamadı. Spearman korelasyon testi sonucunda D vitamini düzeyi ile diğer herhangi bir parametre arasında istatistiksel olarak pozitif veya negatif korelasyon bulunamadı (p>0.05). Sonuç Sonuç olarak bu çalışmada Hashimoto tiroiditi ile D vitamini eksikliği arasında bir ilişki bulunabileceği görüldü. Kontrol grubunda da D vitamini düzeylerinin eksik bulunmuş olması nedeniyle bu çalısmadaki bulgulara bakarak Hashimoto tiroiditi ile D vitamini eksikliğinin korelasyonu ile ilgili net bir yorum getirilemez. Bizim çalışmamızın otoimmun tiroid hastalıkları ile D vitamini eksikliği arasındaki ilişkiyi daha kapsamlı arastıracak çalışmalar için yardımcı olacağını ummaktayız.

Anahtar Kelimeler:

BMI, Hashimoto tiroiditi, TSH, Vitamin D

Comparison of Vitamin D Levels in Patients with Chronic Lymphocytic Thyroiditis and the Normal Population, and Role of Vitamin D on Autoimmunity

Purpose It is known that vitamin D deficiency has a role in the formation of autoimmune diseases, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, diabetes, many types of cancer and heart diseases. This study was conducted to demonstrate the role of vitamin D in Hashimoto's thyroiditis. Methods In this cross-sectional study, the patients who applied to Izmir Bozyaka Training and Research Hospital endocrinology outpatient clinic between the ages of 16 and 50 were evaluated with ultrasonographically consistent with chronic thyroiditis, serologically antibody positive (anti T, anti M), euthyroid, body mass index (BMI) <30, 40 women with Hashimoto's thyroiditis who did not enter menopause, did not have any other additional disease and did not use chronic medication, and 16-50 women who applied to the internal medicine or endocrinology polyclinics of Izmir Bozyaka Training and Research Hospital 40 healthy female patients with a body mass index (BMI) <30 years and negative for thyroid antibodies were recruited. Results When the two groups were compared in terms of age, body mass index, t3, t4, TSH, Anti M, Anti T and vitamin D, no statistically significant difference was found between the two groups. As a result of the Spearman correlation test, no statistically positive or negative correlation was found between vitamin D level and any other parameter (p >0.05). Conclusion In conclusion, in this study, it was seen that there may be a relationship between Hashimoto's thyroiditis and vitamin D deficiency. Since vitamin D levels were found to be deficient in the control group, a clear interpretation cannot be made regarding the correlation of Hashimoto's thyroiditis and vitamin D deficiency based on the findings of this study. We hope that our study will be helpful for further studies that will investigate the relationship between autoimmune thyroid diseases and vitamin D deficiency.

Keywords:

BMI, Hashimoto's Tiroiditis, TSH, Vitamine D,

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