Ersin ÇİNTESUN, Mert BERTİZLİOĞLU, Mete Can ATEŞ, Abdül Hamid GÜLER, Çetin ÇELİK

Gebelerde proteinüri tanısında kullanılan yöntemlerin karşılaştırılması

Amaç Kliniğimizde preeklampsi ön tanısı ile tetkik edilen gebelerde spot idrarda dipstik, protein/kreatinin (P/K) oranı ile 24 saatlik idrarda toplam protein miktarı değerlerinin karşılaştırılması amaçlanmıştır. Gereç ve yöntem Çalışmaya, Ocak 2016–Aralık 2018 tarihleri arasında bir ünivesite hastanesinde preeklampsi ön tanısı ile spot idrarda dipstik yöntemi, P/K oranı ve 24 saatlik idrarda toplam protein analizi yapılan 317 hasta çalışmaya dahil edildi. Hastaların bu üç değeri birbiri ile mukayese edildi. Bulgular Dipstik yönteminin sensitivitesi %67,5; spesifitesi %61,5; doğruluğu %64,3 olarak hesaplandı. 24 saatlik idrarda toplam proteinüri eşik değeri 300 mg/gün olduğunda P/K oranı cut-off değeri 0,34 mg protein/mg kreatinin, sensitivite %68,9, spesifite %78,7 olarak hesaplandı. Spot idrar P/K oranı ile 24 saatlik idrardaki toplam proteinüri değerleri arasında orta düzeyde, anlamlı bir korelasyon gözlendi (R: 0,629 p<0,001). Sonuç 24 saatlik toplam idrar analizi için yeterli zamanın olmadığı acil durumlarda spot idrarda P/K oranının 24 saatlik idrarda toplam protein testine alternatif test olarak kullanılabilir.

Anahtar Kelimeler:

proteinüri, preeklampsi, 24 saatlik idrarda toplam protein miktarı, spot idrarda protein/kreatinin oranı

Comparison of methods used in the diagnosis of proteinuria in pregnant women

Objectives The aim of this study was to compare the total protein content in 24 hours urine with dipstic, protein / creatinine (P / K) ratio in spot urine in our pregnant women who were diagnosed with preeclampsia. Material and Methods In this study, 317 patients who underwent dipstick method, P / K ratio and total protein analysis in 24-hour urine were included in the study with a prediagnosis of preeclampsia at a university hospital gynecology and obstetrics clinic between January 2016 and December 2018. These three values of patients were compared with each other. Results The sensitivity of the dipstik method was 67.5%; specificity 61.5%; accuracy was calculated as 64.3%. When the total proteinuria threshold in the 24-hour urine was 300 mg / day, the P-C ratio cut-off value was 0.34 mg protein / mg creatinine, the sensitivity was 68.9% and the specificity was 78.7%. A moderate, significant correlation was observed between total urinary P / K ratio and total proteinuria in 24-h urine (R: 0.629 p <0.001). Conclusion It can be used as an alternative test in the 24-hour urine total protein test of P / C ratio in spot urine in emergencies where there is not enough time for 24 hour total urine analysis.

Keywords:

proteinuria, preeclampsia, total protein content in 24-hour urine, protein/creatinine ratio in spot urine,

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